Development of new catalytic reactions based on activation of boron and related reagents by chiral carboxylic acid catalysts

我们发现O-单酰基酒石酸是一种有效的不对称有机催化剂，它能活化各种含硼化合物，如烯基硼酸、烯丙基硼酸酯和二硼化合物，从而促进不对称共轭加成和烯丙化反应。为了进一步提高催化剂的选择性和催化活性，考察了催化剂的酰基和羧基的影响。在理论计算的基础上，对催化机理进行了研究。并对催化剂的回收利用进行了研究。

We have found that O-monoacyltartaric acid serves as an effective asymmetric organocatalyst, which can activate various boron compounds such as alkenylboronic acids, allylboronates, and diborons to promote asymmetric conjugate addition and allylation. Effect of the acyl and carboxyl groups of the catalyst was investigated to further improve the selectivity and catalytic activity. The catalytic mechanism was studied based on theoretical calculations. The recovery/reuse of the catalyst was also investigated.