Search of the seeds of an antineoplastic drug and development of a lead compound which marine organism origin fungi produce

我们研究了从各种海洋组织中分离的真菌产生的代谢产物。从海绵真菌中分离得到三个新化合物，其中一个代谢产物的绝对立体结构已确定。从一种海胆源真菌中分离得到一个新化合物，并推测其平面结构。为了确定它的绝对构型，进行了几个化学反应，并将很快完成。我们仔细研究了产生细胞毒性物质的真菌。因此，许多新的物质被分离，其中一些表现出对癌细胞系的生长抑制的有效活性。

We studied the metabolites produced the fungi separated from the various marine organizaition. New three compounds were isolated from the marine sponge-derived fungus, and the absolute stereostructure for one metabolites was established. A novel compound was isolated from a sea urchin-derived fungus, and the planar structure was deduced. In order to the detrermination for the absolute configuration of it, several chemical reactions were carried out, and will copmpete soon. We scrutinized succeedingly about the cytotoxic substance production fungus. Consequently, many new substances were isolated and some of them demonstrated potent activities for the growth inhibition against the cancer cell lines.