Research on active compounds from natural resources affecting the differentiation of ES and iPS cells

从植物中分离出一些新的化合物和已知的化合物。新化合物的结构通过光谱分析得到了证实。分离得到的几个化合物显示出以下有用的生物活性：severibuxine、murrayafoline-A和murrayazoline通过引起细胞凋亡显著抑制HL-60白血病细胞的生长；兰沙胺I、兰沙胺B和SB-204900显著降低RBL-2H3细胞的组胺释放；拉帕适能降低增生性瘢痕成纤维细胞的增殖速率。分离得到了一种从木参中分离得到的芳香族化合物；其中，几种苯甲醛衍生物表现出较高的自由基清除活性。以murrayaquinone-A为先导化合物合成的三个carbazolequinone衍生物抑制LPS/ ifn诱导的NO生成。未发现影响胚胎干细胞和诱导多能干细胞分化的种子化合物；然而，未来的研究是有计划的。

Several new compounds were isolated from plant sources together with known compounds. The structures of the new compounds were elucidated by spectroscopic analyses. Several of the isolated compounds exhibited the following useful biological activities: severibuxine, murrayafoline-A, and murrayazolinine significantly suppressed the growth of HL-60 leukemia cells by causing apoptosis; lansamide I, lansiumamide B, and SB-204900 significantly decreased histamine release from RBL-2H3 cells; and lapachol decreased the proliferation rate of hypertrophic scar fibroblasts. Aromatic compounds produced by Eurotium herbariorum from a karebushi were isolated; of these, several benzaldehyde derivatives exhibited high radical scavenging activity. Three carbazolequinone derivatives, synthesized using murrayaquinone-A as a lead compound, inhibited LPS/IFN-induced NO production. No seed compounds affecting the differentiation of ES and iPS cells have been found; however, future research is planned.