Roles epigenetics regulatory factors induced hepatocarcinogenesis in malignant transformation and defense against cancer.

核DNA包裹在组蛋白周围并包装成染色质。基因表达受染色质结构变化的调节，染色质结构变化由组蛋白的化学修饰、组蛋白变体取代经典组蛋白等介导。组蛋白修饰的失调以及组蛋白修饰酶和组蛋白变体的表达导致包括癌症在内的疾病。在这项研究中，我们发现组蛋白甲基转移酶与转录因子的相互作用与癌症的发生有关。此外，我们发现组蛋白变体的表达在自噬过程中减少，这与癌症的促进和抑制有关。

Nuclear DNA wraps around histone proteins and is packaged into chromatin. Gene expression is regulated by structure changes of chromatin mediated by the chemical modification of histone, the replacement of canonical histone by histone variants, etc. Dysregulation of histone modification and expression of histone modification enzymes and histone variants leads to diseases including cancer. In this study, we revealed that histone methyltransferase interacted with transcription factors in concerned with carcinogenesis. Further, we found that expression of histone variants was decreased during autophagy, which is involved in promotion and suppression of cancer.