Malaria vaccine platform technology

由于重组疟疾抗原固有的弱免疫原性，阻碍了预防疟疾感染的亚单位疫苗的开发。我们已经建立了一个新的系统，称为三组分免疫增强系统（TIPS），以增加免疫反应，通过创建遗传蛋白融合的目标B淋巴细胞在引流淋巴结的免疫动物。TIPS由抗原、卷曲螺旋核心和靶向配体组成。我们发现在TIPS中整合疫苗抗原显著增强了抗原的免疫原性和疫苗效力。

Development of subunit vaccines to prevent malaria infection has been hampered by the intrinsic weak immunogenicity of the recombinant malaria antigens. We have establised a novel system called tricomponent immunopotentiating system (TIPS) to increase immune responses by creating genetic protein fusions to target B lymphocytes in the draining lymph nodes of immunized animals. TIPS is composed of the antigen, coiled-coil core and the targeting ligand. We found that integration of vaccine antigens in the TIPS significantly augmented the immunogenicity and vaccine efficacy of the antigens.