Effects of n-3 unsaturated fatty acid on ischemic heart disease: evaluation of LDL choesterol function

高甘油三酯血症患者被随机分为对照组和EPA组，在EPA组，血清低密度脂蛋白和高密度脂蛋白水平保持不变，但低密度脂蛋白明显增大，富含甘油三酯的脂蛋白(TRL)水平显著降低。EPA/AA升高是与低密度脂蛋白大小增加相关的独立变量。TRLS与低密度脂蛋白颗粒大小呈负相关。EPA通过改善TG代谢来增加低密度脂蛋白的大小，EPA/AA可能是增加低密度脂蛋白大小的有用标记物。这项横断面研究表明，即使在日本的城市环境中，来自鱼类消费的较高的EPA和DHA水平也与较低的冠状动脉疾病患病率相关。较高的EPA和DHA水平是apoA-1水平较高的自变量。

Hypertriglyceridemic subjects were randomly assigned to a control group or an EPA group.In the EPA group,the serum LDL-C and HDL-C levels remained unchanged, but there was a significant increase in LDL size and a significant decrease in TG-rich lipoproteins (TRLs) levels. Elevation of EPA/AA was independent variable associated with the increase in LDL size. Negative correlations were found between TRLs and LDL particle size. EPA administration increases LDL size by improving TG metabolism, and EPA/AA may be useful markers of increased LDL size.The cross-sectional study suggested that higher serum levels of EPA and DHA derived from fish consumption are associated with lower coronary artery disease prevalence even in an urban environment in Japan. Higher EPA and DHA levels were independent variables of a higher apoA-1 level.