Relation of leptin and adiponectin to subclinical atherosclerosis

瘦素高浓度组平均内膜-中膜厚度（IMT）和Agaston评分显著增高，脂联素高浓度组显著降低。在校正混杂因素的多元线性回归模型中，对数瘦素和对数脂联素与IMT无关。在年龄调整后的logistic回归模型中，log-leptin与CAC呈显著正相关（Agaston评分>=10），但在多混杂因素调整后的模型中，log-leptin与CAC呈显著负相关。在年龄调整模型中，log -脂联素与CAC显著直接相关，但在多变量调整模型中，log -瘦素与CAC显著负相关。在本研究的多变量分析中，瘦素与CAC呈负相关关系，可能支持瘦素在减肥中的临床应用。

Mean intima-media thickness (IMT), and Agaston score were significantly greater in the higher leptin concentration groups, and were significantly lower in the higher adiponectin concentration groups. In multiple linear regression models adjusted for confounders, log-leptin and log-adiponectin did not relate to IMT. In logistic regression models adjusted for age, log-leptin was significantly directly related to CAC (Agaston score>=10), but significantly inversely related to CAC in a model adjusted for multiple confounders. Log-adiponectin did not relate to CAC.Log-leptin was significantly directly related to CAC in an age-adjusted model, but was significantly inversely related to CAC in a multivariable adjusted model. The inverse relation of leptin to CAC in multivariable analysis in this study may support clinical use of leptin in weight reduction.