Establishment of early diagnosis method for esophageal cancer by mass spectrometry

在这项研究中，我们进行了代谢组学分析的食管癌患者，这项研究的目的是发现生物标志物，是有用的食管癌的早期检测。结果，我们发现了17种代谢物，这些代谢物在食管癌的发病过程中发生了显着变化，通过代谢组学分析，使用气相色谱/质谱。通过液相色谱/质谱联用脂质代谢物组学分析，发现47种脂质代谢物发生了显著变化;通过液相色谱/质谱联用阳离子/阴离子代谢物组学分析，发现13种代谢物发生了显著变化。这些显著变化的代谢物可能是食管癌生物标志物的候选者。

In this study, we performed metabolome analysis of esophageal cancer patients, and the aim of this study was to discover the biomarkers that are useful for early detection of esophageal cancer. As a result, we found the 17 metabolites that were significantly changed by the pathogenesis of esophageal cancer by metabolome analysis using gas chromatography/mass spectrometry. By lipid metabolome analysis using liquid chromatography/mass spectrometry, we discovered the 47 lipid metabolites with the significant alterations, and by cation/anion metabolome analysis using liquid chromatography/mass spectrometry, we found the 13 metabolites with the significant alterations. These significantly-changed metabolites may be candidates for esophageal cancer biomarkers.