Expression and its functional role of Beta3-adrenoceptors in the human prostate

RT-PCR证实人前列腺中β 1-、β 2-和β 3-AR mRNA的表达。在免疫组化上，不仅在前列腺平滑肌中，而且在腺上皮中鉴定出β 1-、β 2-和β 3-AR的阳性染色。在体外药理学研究中，β 3-AR激动剂浓度依赖性地减少KCl或EFs诱导的人正常前列腺条的收缩。总之，β 3-AR激动剂可能对良性前列腺增生或神经源性膀胱引起的下尿路症状具有临床获益。

Expression of beta1-, beta2- and beta3-AR mRNA in the human prostate was confirmed by RT-PCR. On immunohistochemistry, positive staining for beta1-, beta2- and beta3-AR was identified not only in prostatic smooth muscles, but also glandular epithelium. In pharmacological study in vitro, a beta3-AR agonist concentration-dependently decreased KCL- or EFS-induced contraction of the human normal prostatic strips. In conclusion, beta3-AR agonists may have clinical benefit for lower urinary tract symptom due to either benign prostatic hyperplasia or neurogenic bladder.