Research the regulators, including cytokine, of intratumoral biosynthesis of estrogen in endometrial cancer microenvironment

子宫内膜癌组织中性类固醇激素和应激激素浓度升高。另一方面，我们发现类固醇硫酸酯酶通过肿瘤间质细胞在子宫内膜癌中的局部雌激素合成中起着非常重要的作用。 细胞相互作用因此，类固醇硫酸酯酶抑制剂应该是有用的药物，特别是对于子宫内膜癌患者，其具有类固醇硫酸酯酶活性。

Intratumoral concentrations of sex-steroid hormone and stress hormone wereelevated in the endometrial carcinoma. On the other hand, we indicated steroid sulfatase played a veryimportant role in the local biosynthesis of estrogen in human endometrial cancer through tumor-stromal cell interactions. Therefore, steroid sulfatase inhibitors should be useful drugs especially for patients with endometrial cancers, which have steroid sulfatase activities.