The study of the gene distribution and the role in hard tissue formation of amelogenin

原位杂交结果显示，釉原蛋白基因在非牙源性组织如脑、肾、眼和骨组织中均有表达，与切牙成釉细胞相比，有少量表达。釉原蛋白基因在组织中的表达水平在妊娠晚期比胎儿早期增强的趋势已被证实。

According to the results of in situ hybridization, amelogenin gene expression was observed several non tooth related tissue such as brain, kidney, eye and bone related tissues.The amelogenin gene expression in these tissues, were a significant small amount of gene expression compared with gene expression in ameloblast of incisor. The tendency of the expression level of the amelogenin gene in the tissue they become strong in the late gestation than early fetal period has been confirmed.