Rapid screening of gene(s) related to the phenotype of model rats with high levels of voluntarily wheel running activity

为了确定Wistar大鼠自发性跑轮运动（spontantan-runningtokushima - shikoku， SPORTS）模型大鼠表型可能相关的基因和分子通路，我们利用下一代测序仪进行外显子组测序，利用基因组和多态性数据库进行连锁分析和选择算法相结合，建立了一种新的综合筛选系统。通过本研究，我们成功建立了一种新的大鼠基因组分析筛选系统，并鉴定出一组与sport大鼠表型相关的候选基因。

In order to identify gene(s) and molecular pathway(s) possibly related to the phenotype of model rats with high levels of voluntarily wheel running activity(Spontaneously-Running-Tokushima-Shikoku, SPORTS) established from Wistar rats, we established a novel integrated screening system through combining exome sequencing using a next-generation sequencer, linkage analysis, and selection algorithm using genome and polymorphism databases. Through this study, we successfully established a novel screening system for rat genome analysis and identified a set of candidate genes related to the phenotype of SPORTS rats.