Signal-dependent generation and function of the actin filament arrays defined by SWAP-70

动态细胞骨架允许细胞改变其形态和细胞内组织。肌动蛋白细胞骨架由功能不同的肌动蛋白丝阵列亚群组成，这些亚群有助于细胞迁移、形状改变、粘附以及细胞外和质膜成分的摄取。通过与SWAP-70蛋白的关联，我们发现了一个迄今为止未被识别的肌动蛋白丝动态亚群。我们现在计划阐明这个肌动蛋白丝亚群的形成和功能。此外，我们希望了解控制SWAP-70靶向这些肌动蛋白丝的信号通路和分子机制，以及SWAP-70如何调节肌动蛋白组织。

A dynamic cytoskeleton allows cells to change their morphology and intracellular organization. The actin cytoskeleton consists of functionally different subsets of actin filament arrays that contribute to cell migration, shape changes, adhesion, and uptake of extracellular and plasma membrane components. We have identified a hitherto unrecognised dynamic subpopulation of actin filaments by the association with the protein SWAP-70. We now plan to elucidate the formation and function of this subpopulation of actin filaments. Furthermore, we want to understand what signaling pathways and molecular mechanisms control the targeting of SWAP-70 to these actin filaments and how SWAP-70 modulates the actin organization.