New therapeutic strategy with SMTP for acute cerebral ischemia

采用小鼠短暂局灶性脑缺血模型，评价SMTP对急性脑缺血的治疗效果。与载药组相比，经静脉注射SMTP成功缩小脑梗死面积。脑血流分析表明，SMTP降低了再灌注后CBF的显著增加，并诱导CBF逐渐恢复。与载体组相比，smtp处理组的超氧化物生成、自由基反应生成和内皮破坏标志物显著降低。结果表明，SMTP不仅具有纤溶作用，而且具有抗短暂性脑缺血再灌注后氧化损伤的作用。

We evaluated effectiveness of SMTP for acute cerebral ischemia using mouse transient focal cerebral ischemia model. SMTP was intravenously injected and successfully reduced size of cerebral infarction compared with the vehicle group. Cerebral blood flow analysis demonstrated that SMTP reduced remarkable increase of CBF after reperfusion and induced gradual CBF recovery. Superoxide production, radical reactive production and endothelial destruction marker was significantly reduced in SMTP-treated group compared with the vehicle group. Our results indicate that SMTP administration might induce not only fibrinolytic effectiveness, but also anti-oxidative injury after reperfusion due to transient cerebral ischemia.