Monitoring of neuroinflammation and creation of new strategy after spinal cord injury.

小胶质细胞和巨噬细胞（MG/MF）依赖于独特的细胞因子刺激而具有多种功能，并在中枢神经系统疾病期间促进神经细胞死亡、修复和重塑。虽然IL-1已被证明会加剧炎症，但它也被认为会增强神经变性。我们在IL-1基因敲除（KO）小鼠的体内脊髓损伤（SCI）模型中确定MG/MF的活化表型和IL-1的影响。此外，我们证明了IL-1的贡献，在体外使用成人MG原代culture.We证明在这里在体内实验中，IL-1抑制SCI的过程中介导的炎症反应的减少MG的经典和替代激活。此外，我们认为，IL-1参与MG的经典和替代激活在体内和体外系统。骨髓间充质干细胞移植到损伤的脊髓已被公认为改善运动功能，神经炎症和再生。

Microglia and macrophages (MG/MF) have a diverse range of functions depending on unique cytokine stimuli, and contribute to neural cell death, repair, and remodeling during central nervous system diseases. While IL-1 has been shown to exacerbate inflammation, it has also been recognized to enhance neurodegeneration. We determined the activating phenotype of MG/MF and the impact of IL-1 in an in vivo spinal cord injury (SCI) model of IL-1 knock-out (KO) mice. Moreover, we demonstrated the contribution of IL-1 to both the classical and alternative activation of MG in vitro using an adult MG primary culture.We demonstrate here in in vivo experiments that IL-1 suppressed SCI in a process mediated by the reduction of inflammatory responses. Moreover, we suggest that IL-1 participates in both the classical and alternative activation of MG in in vivo and in vitro systems. hMSCs Implanted to injured spinal cord have been recognized to improve motor function, neuroinflammation and regeneration.