Primary bone graft for cleft lip and palate using umbilical cord-derived mesenchymal stem cells

唇腭裂的产前诊断是准确的。我们研究了出生时采集的脐带间充质干细胞在出生后3至6个月用于牙周骨膜成形术和植骨的临床适用性。二次植骨，通常在患者5-10岁时使用髂骨松质骨进行，具有良好的效果。我们的研究结果显示，脐带来源的间充质干细胞的质量与髂骨松质骨来源的间充质干细胞的质量不同，因为脐带来源的间充质干细胞很难分化为骨细胞。我们发现脐带来源的间充质干细胞移植模型的骨形成与非细胞移植模型的骨形成没有差异。对受体利基的研究可能与细胞质量一样重要。

Prenatal diagnosis of cleft lip and palate is accurate. We investigated the clinical applicability of umbilical cord-derived mesenchymal stem cells harvested at birth for primary gingivoperiosteoplasty and bone grafting 3 to 6 months after birth. Secondary bone grafting, which is usually performed when the patient is 5 to 10 years old using iliac cancellous bone, provides good results.Our findings revealed that the quality of umbilical cord-derived mesenchymal stem cells differed from that of iliac cancellous bone-derived mesenchymal stem cells, because differentiation of umbilical cord-derived mesenchymal stem cells into bone cells was difficult to achieve. We detected no difference between the bone formations in the umbilical cord-derived mesenchymal stem cell graft model and those of the non-cell graft model using the nude mouse with partial maxillary defects. Studies of the recipient niche might be as important as the cell quality.