Development of jaw bone reconstruction material made of osteoconductive titanium fiber mesh scaffold.

本研究的目的是评价涂覆一层薄层羟基磷灰石(HA)的钛纤维支架的骨再生性能。人成骨细胞培养表明，羟基磷灰石包被的TFS促进了成骨细胞的活性。采用钛纤维骨块修复兔下颌骨节段性骨缺损。新生骨在HA/TFS内和表面完全再生，提示TFS是修复颌骨缺损区的理想材料。

The aim of this study was evaluation of the bone regeneration properties of titanium fiber scaffold (TFS) that had been coated with a thin hydroxyapatite (HA) layer. Human osteoblasts culture suggested that the HA coated TFS accelerated osteoblast activity. Reconstructive surgery for rabbit mandibular segmental bone defect using titanium fiber block was performed. The discontinuity of the mandibular bone was completely regenerated by newly formed bone in and on the HA/TFS, suggesting TFS is the materials to reconstruct the jaw bone defects.