Development of the Continuous Microflow Reaction and Multi StepProcess

我们开发了银或锌催化的不对称烯丙基化反应、硫醇与烯酮的不对称Michael反应以及水中不对称的硼共轭加成反应。这些反应适合于连续微流反应。此外，我们还开发了用于烯丙化反应的固定化锌催化剂，并将其应用于流动合成。通过对流速、溶液浓度等条件的优化，得到了产率高、产率高的产品。

We have developed a silver or zinc catalyzed asymmetric allylation reactions, asymmetric Michael reactions of thiols with enones and enantioselective boron conjugate additions in water. These reactions are suitable for continuous microflow reaction. Moreover, we have developed immobilized zinc catalyst for allyration reactions, and an application to flow synthesis. After optimization of flow rates, concentration of solutions, and other conditions, an excellent yield, also with good productivity were obtained.