Hydration of organic compounds catalyzed by metal porphyrins

我们已经开发了水溶性钴（III）卟啉配合物，促进末端炔水合产生甲基酮。炔水合与酸/碱或氧化还原敏感性官能团如烷基甲硅烷基醚、烯丙基醚、三苯甲基醚、苄基醚、羧酸酯、硼酸酯、羧酰胺、腈和缩醛基团的存在相容。在此测试的一些炔底物在其他方面难以水合。反应机理也澄清使用光谱，动力学和理论方法。

We have developed water-soluble cobalt(III) porphyrin complexes that promote the hydration of terminal alkynes to produce methyl ketones. The alkyne hydration was compatible with the presence of acid/base- or redox-sensitive functional groups such as alkyl silyl ethers; allyl ethers; trityl ethers; benzyl ethers; carboxylic esters; boronic esters; carboxamides; nitriles; and acetal groups. Some of the alkyne substrates tested here are otherwise difficult to hydrate. The reaction mechanism was also clarified using spectroscopic, kinetic, and theoretical methods.