Development ofrapid cancer diagnosis by the novel electrospray ionization-mass spectrometry

探针电喷雾电离(PESI)是一种生物相容的环境电离技术。我们确定了人体组织中脂质的测量条件。从人肾细胞癌和肝细胞癌的标本中获得了3000多个光谱数据集。这些数据被用作训练数据集，作为dPLRM的参考。我们将随机选择的测试数据集输入到dPLRM中，以获得癌症诊断的概率结果。与常规组织病理学诊断符合率达90%以上。

Probe electrospray ionization (PESI) is a biocompatible ambient ionization technique. We determined the conditions of measurements for lipids in human tissues. More than 3,000 spectra datasets were obtained from specimens of human renal cell carcinoma and hepatocellular carcinoma. These data were used as a training dataset, which serves as a reference for the dPLRM. We input randomly selected test datasets to the dPLRM to get probabilistic result of cancer diagnosis. We achieved over 90% coincidence of diagnosis with those judged by the conventional histopathology.