Metabolic and immunological impacts of growth hormone treatment in children with short stature born small for gestational age

我们研究了生长激素治疗(GH-TX)对小于胎龄儿(SGA)的代谢和免疫功能的影响。我们还评估了患者GH-TX前的代谢和免疫学参数，并与健康对照组进行了比较。结果表明，GH-TX治疗3个月后身高-抑郁改善与血清IGF1水平升高成正比。SGA患儿GH Tx前HbA1c水平高于对照组，GH Tx后HbA1c水平未见恶化。生长激素TX可降低低密度脂蛋白胆固醇水平，提示生长激素具有良好的脂代谢作用。同样，GH-TX显著改变了许多血清载脂蛋白水平。GH-TX前患者外周血中白细胞、中性粒细胞、淋巴细胞计数及淋巴细胞亚群与对照组比较差异有统计学意义。患者的GH-TX改变了这些血液学参数的水平，而不是对照组。

We studied on metabolic and immunological effects by growth hormone treatment (GH Tx) for one year in children with short stature born small for gestational age (SGA). We also evaluated the metabolic and immunological parameters for the patients before GH Tx compared with those for healthy controls. As a result, height SDS was improved 3 months after starting GH Tx in proportion to increase of serum IGF1 level. The HbA1c level before GH Tx in SGA children was higher than in controls, however, it did not worsen after GH Tx. The LDL-C level decreased by GH Tx, which indicated favorable effects of GH on lipid metabolism. Similarly, the many of serum apolipoprotein levels were considerably altered by GH Tx. Differences in counts of the white blood-cell, the neutrophil and the lymphocyte, and population of lymphocyte subsets were observed in between the patients before GH Tx and controls. GH Tx for the patients changed the levels of these hematological parameters toward those in controls.