Role of molecular clock on the communication between each organ in organ dysfunction

慢性肾脏疾病（CKD）增加中风、心力衰竭、心肌梗死和神经系统并发症的疾病风险。然而，这些神经系统并发症的机制尚不清楚。在这里，我们展示了5/6肾切除术小鼠慢性肾衰竭对24小时纹状体多巴胺受体和时钟基因表达节律以及肝脏细胞色素P450 （CYPs）的破坏性影响。这些破坏性影响是由肾中高表达因子X的异常信号转导引起的。

Chronic kidney disease (CKD) increases the disease risk of apoplexy, cardiac failure, cardiac infarction and neurological complications. However, the mechanisms of these neurological complications remain unclear. Here, we showed the disruptive effect of chronic renal failure in 5/6 nephrectomy mice on the 24-hr rhythm of dopamine receptor and clock gene expressions in the striatum and cytochrome P450 (CYPs) in liver. These disruptive effects were induced by abnormal signal transduction in high Factor X expression from the kidney.