Study on the treatment of highly pathogenic avian influenza H5N1 infections by means of the analysis of pathogenesis of the illness

H5 N1亚型高致病性禽流感在人类中的发病机制与重症肺炎和流感相关脑病的细胞因子风暴非常相似。利用微阵列分析，我们分析了2009年pdm感染急性期的基因表达。有趣的是，基因表达谱在帕金森病患者和CNS表现的患者之间是不同的。特别是与ROD相关的基因表达被高度激活。在小鼠模型中，我们发现硫氧还蛋白-1（TRX）可以抑制氧化应激和炎症反应，从而改善流感病毒感染性肺炎的预后。总之，抗氧化应激药物如TRX可能在H5 N1感染的重症肺炎/ARD中发挥重要作用。

The pathogenesis of highly pathogenic avian influenza H5N1 in humans has been closelsimilar to those of severe pneumonia and influenza-associated encephalopathy witcytokine storm. Using microarray assay we have analyzed gene expression in the acute phasof 2009pdm infection. Interestingly, gene expression profiles were different betweepneumonia patients and patients with CNS manifestations. Particularly, gene expressiorelated to ROD has been highly activated. Using mouse model, we have shown that thioredoxin-1(TRX) could suppress the oxidativstress and inflammatory changes resulting better outcome in pneumonia with influenzvirus infections. Taking together, anti-oxidant stress agents such as TRX could play an important rolin the severe pneumonia/ARD with H5N1 infections.