Dental Pulp treatment using artificial protein with biomeneralization

当牙齿因龋齿或外界损伤而受到阻碍时，因患者疼痛而难以挽救牙髓组织。然而，牙髓拔除处理在许多情况下会造成根尖周病变，如根尖囊肿。这个项目的目的是让牙髓本身钙化。因此，启动生物矿化的多肽适配子(与特定分子特异性结合的多肽)与占据牙髓室、神经纤维和血管的大部分成分的胶原蛋白结合。我们试图促使活体中的牙髓腔钙化。我们已经发表了开发适体结合钛或锆的适体，方向性(Biomacromelecules，9：3098-3105,2008，牙科材料杂志30：935-940,2011)的论文。此外，该论文也是通过体内实验获得的。材料。2013年版。在研究期间，发明了与胶原、神经纤维和血管结合的多肽适配子，筛选出启动生物矿化的适配子，并进行了体外功能检测。研究将考虑临床应用，并将从现在开始继续进行。

When the tooth received the obstacle owing to dental caries or externally caused injury, it was difficult to save the dental pulp tissue because of a patient's pain. However, dental-pulp-extraction disposal makes a peri-apical lesion such as radicular cyst in many cases. The purpose of this project was to make a pulp calcify itself. Therefore, the peptide aptamer (peptide specifically combined with a specific molecule) which starts biomineralization combines with the collagen which occupies most components of a pulp chamber, a nerve fiber, and a blood vessel . We tried to urge calcification of the pulp chamber in the living body. We already published the paper in which we develop the aptamer bind either titanium or zirconium, directivity(Biomacromelecules, 9: 3098-3105, 2008, Dental Materials Journal 30: 935-940, 2011).Moreover, also by in vivo, the paper was received by J Biomed. Materials. Res. 2013 . Within study duration, the peptide aptamer combined with collagen, a nerve fiber, and a blood vessel was invented, the aptamer which starts biomineralization was selected, and the function was checked by in vitro. Research is due to consider clinical application to be the selection and to be continued from now on.