Tailor-made bone regeneration as a pre-prosthodontic treatment based on the concept of tissue engineering triad

根据组织工程三位一体的原理，细胞、生物活性分子和支架被认为是再生所必需的。从这一点上推测，并不是每个预期增加骨组织的部位都需要相同的元素。从我们的实验结果来看，局部应用成骨细胞分化因子和成骨细胞增殖因子都可以诱导骨形成。但前者诱导的骨比后者诱导的多为矿化骨。此外，成骨细胞分化因子刺激成骨样细胞中的Smad信号通路。

According to the principle of tissue engineering triad, cells, bioactive molecules, and scaffold are thought to be essential for regeneration. From this point, it is supposed that not every site expected to augment bone tissue requires same element.From the results of our experiments, the local application of both osteoblast-differentiation factor and osteoblast-proliferation factor could induce bone formation. But the bone induced by the former represented more mineralized bone than that induced by the latter. In addition, osteoblast-differentiation factor stimulated the Smad-signaling pathway in the osteoblast-like cells.