Dopamine D2 receptor dysfunction in the extra-striatal region in maternal immune activation rodent model

采用micro-PET技术研究了精神分裂症母体免疫激活（MIA）大鼠模型全脑D2 Rs放射性配体11 C-FLB 457的结合潜力。结果发现，MIA模型大鼠前扣带皮层（ACC）的11 C-FLB 457结合电位明显低于纹状体外其他区域。在ACC中，成熟的多巴胺D2受体蛋白表达和小白蛋白（PV）阳性中间神经元也减少。我们的发现MIA模型与一些以前的PET和尸检研究精神分裂症患者。因此，我们的MIA模型的发现强烈地提出了ACC中D2 R和神经元间改变是精神分裂症的重要病理之一的可能性。

We investigated D2Rs radio-ligand such as 11C-FLB457 binding potential in the whole brain of maternal immune activation (MIA) rat model with schizophrenia by micro-PET. We found that statistic of 11C-FLB457 binding potential in the anterior cingulate cortex (ACC) of MIA rat model was much lower than another extra-striatal regions by micro-PET. In the ACC, both mature dopamine D2 receptor protein expression and parvalbumin (PV) positive interneurons were also decreased. Our finding of MIA model was in agreement with some of previously both PET and postmortem studies with schizophrenia patients. Hence, Our finding of MIA model strongly raise the possibility that D2R and interneuronal alteration in the ACC are one of the important pathology in schizophrenia.