Macrophages are associated with exercise-induced increase in insulin sensitivity

运动是增强骨骼肌胰岛素敏感性的有力工具，然而，其确切的机制目前还不清楚。我们假设巨噬细胞，尤其是抗炎的M2巨噬细胞，与运动后肌肉胰岛素敏感性的增加有关。单次跑台运动可增加PBS-EX组大鼠骨骼肌中M2巨噬细胞的数量。而CL-EX组运动后M_2巨噬细胞数未见增加。随着M2巨噬细胞的改变，PBS-EX组胰岛素刺激的2-DG摄取在单次运动后24小时显著增加，而CL-EX组则无明显变化。根据这些结果，我们得出结论，M2巨噬细胞参与了运动诱导的肌肉胰岛素敏感性的增加。

Exercise is a powerful tool to enhance insulin sensitivity in skeletal muscle, however, the precise mechanisms are largely unknown. We hypothesized that macrophages, especially anti-inflammatory M 2 macrophages, are associated with increase in muscle insulin sensitivity after exercise. A single bout of treadmill running increased number of M2 macrophages in skeletal muscle in PBS-ex group. On the other hand, in CL-ex group, number of M2 macrophages were not increased after exercise. Concomitant with change of M2 macrophages, insulin-stimulated 2-DG uptake was increased 24 h after a single bout of exercise in PBS-ex group, however, CL-ex group were not. From these results,we concluded that M2 macrophages are involved in exercise-induced increase in muscle insulin sensitivity.