Backbone Modified Cyclic Peptides: Scaffolds for Supramolecular Chemistry

模拟大自然催化剂的化合物--酶--的合成将使我们更好地了解这些有趣的分子是如何发挥作用的，并可能导致工业过程中新型催化剂的开发。修饰的环肽可以作为平台，以空间定义良好的方式排列催化基团，以模拟酶。由于环肽通常很难制备，我的目标是开发一种强大的通用方法来合成它们。这一方法将被应用于环肽类酶模拟物的合成。

The synthesis of compounds that mimic Nature's catalysts - enzymes - will provide us with a better understanding of how these intriguing molecules function and may lead to the development of new catalysts for industrial processes. Modified cyclic peptides could be used as platforms to arrange catalytic groups in a spatially well-defined manner to mimic enzymes. As cyclic peptides are often difficult to prepare, I aim to develop a powerful general method for their synthesis. This methodology will then be applied to the synthesis of cyclic peptide-based enzyme mimics.