Roles of secretin-oxytocin system in the control of social recognition/ memory.

促胰液素激活视上核内的催产素神经元，促进催产素的中枢释放。视上核局部应用促胰液素可促进社会识别/记忆。催产素对社会识别/记忆的促进作用可被杏仁内侧核或催产素受体缺陷小鼠体内注射的催产素受体拮抗剂所抑制。此外，催产素治疗恢复了分泌素受体缺陷小鼠的社会识别/记忆。所有这些结果表明，新定义的分泌素-催产素系统在调节社会记忆/再认中起着关键作用。

Secretin activated oxytocin neurons of the supraoptic nucleus and facilitated oxytocin release centrally. Local application of secretin into the supraoptic nucleus facilitated social recognition/ memory. The facilitative effects of secretin upon social recognition/ memory were inhibited by an oxytocin receptor antagonist injected into the medial amygdala or in oxytocin receptor-deficient mice. Furthermore, oxytocin treatment restored social recognition/ memory in secretin receptor-deficient mice. All these results suggest that newly defined secretin-oxytocin system plays a critical role in regulating social memory/ recognition.