The cognitive control of long-term memory: Neural dynamics in space and time

一般认为，长时记忆是由控制过程介导的，控制过程引导记忆提取，以选择性地恢复与当前任务和目标相关的信息。控制性记忆提取是由内侧颞叶（MTL）、前额叶皮层（PFC）和其他皮层区域之间的动态相互作用引起的。近年来的功能成像、事件相关电位和神经心理学研究已开始揭示控制性记忆提取的子过程及其相关的神经机制。然而，重要的问题，有关的动态相互作用的上述大脑系统完成控制的记忆检索仍然没有得到解决。使用组合事件相关电位（ERP）和EEG变量，除了interareal相位同步的措施，本建议的目的是在检查检索方向，即检索线索发起的处理的具体形式，和它们的神经相关。详细地说，我们要调查的因素有助于启动和维持的检索取向和这些控制过程的影响，对其他组成部分的记忆检索。

It is generally assumed that long-term memory is mediated by control processes that guide memory retrieval in order to selectively recover information relevant for current tasks and goals. Controlled memory retrieval results from a dynamic interplay between the medial temporal lobe (MTL), the prefrontal cortex (PFC), and other cortical areas. Recent functional imaging, ERP and neuropsychological studies have started to disclose the subprocesses of controlled memory retrieval and their neural correlates. However, important issues concerning the dynamic interplay of the aforementioned brain systems accomplishing controlled memory retrieval are still unresolved. Using combined event-related potential (ERP) and EEG variables in addition to measures of interareal phase synchrony, the present proposal aims at examining retrieval orientations, i.e. the specific form of processing initiated by a retrieval cue, and their neural correlates. In detail we want to investigate factors contributing to the initiation and maintenance of retrieval orientations and the influence of these control processes on other components of memory retrieval.