Integrated Nanoplatform for Multiomics Analysis of Cell-to-Cell Interaction

该项目旨在开发一个集成的纳米平台，用于在单细胞水平上分析宿主与病原体相互作用产生的外切体。这将通过设计一种创新的装置来实现，该装置涉及等离子体纳米颗粒，可以随着时间的推移探测外体分子图谱。预期的结果是一个通用的、强大的平台，用于对细胞间相互作用的后果进行详细的分子分析。单细胞尺度将极大地提高对异质细胞群体的检测精度。好处将包括制造中细胞间通信和知识产权的新知识，这将通过提供新的技术解决方案促进跨机构和澳大利亚行业的合作。

This project aims to develop an integrated nanoplatform for analysis of exosomes produced by host-pathogen interaction at the single cell level. This will be accomplished by engineering an innovative device involving plasmonic nanoparticles to probe exosomes molecular profiles over time. The intended outcome is a generic and robust platform for detailed molecular analysis of the consequences of cell-to-cell interactions. Single cell scale will greatly improve detection accuracy for heterogeneous cell populations. Benefits will include new knowledge of cell-to-cell communication and intellectual property in manufacturing, which will foster collaborations across institutions and Australian industry by providing new technological solutions.