Roles of vasoacting peptides of the improvement of hypertension by exercise

采用跑步机训练Wistar大鼠8周。训练强度逐渐增加至25 rn/rn，持续90 min。最后的训练结束后，从大鼠身上切除器官，用于受体结合试验，测量第二信使，释放激素或葡萄糖。第一年使用粗膜制剂进行了一些实验，但值很低，无法检测到。第二年，分离的细胞被用于实验。得到了以下结果：1)静息血压未因运动训练而降低。2)肾脏AVP受体的数量和亲和力不受训练的影响，但Vi受体刺激诱导的IP_3合成明显增加。3)血管紧张素II刺激的醛固酮释放量随着训练的增加而减少。4)内皮素A受体的亲和力通过训练增强。5)内皮素刺激的葡萄糖释放随着训练而减少。由此可见，运动训练改变了血管作用肽的作用。

Wistar rats were trained for 8 weeks by running with treadmil. The training intensity was gradually increased to 25 rn/rn in for 90 min. After the final training, organs were excised from the rats and used for receptor binding assay, measurement of the 2nd messenger, released hormone or glucose. For the first year, crude membrane preparations were used for some experiment, but the value was very low and was not detectable. For the second year, isolated cells were used for the experiment. The following results were obtained.1) Resting blood pressures did not decreased by the exercise-training.2) The number of renal AVP receptors and affinity did not changed by the training, but the synthesized IP_3 induced by Vi receptor stimulation were significantly increased b y the training.3) Angiotensine II stimulated aldosterone released from ad renals were decreased by the training.4) Affinity of endotheline A receptor was increased by the training.5) Endotheline stimulated glucose release was decreased by the training.It was concluded that exercise-training modifies the action of vasoacting peptides.