Nitroxide-containing scaffolds for controlling biofilm-related infections

细菌生物膜是世界各地卫生保健系统中的一个主要问题，因为它们会导致持续和慢性感染，包括与医疗植入物和囊性纤维化相关的感染。该项目旨在开发新的化学方法，在表面界面和微粒中输送氮氧化物，以促进对生物膜生长的长期控制。预计这些功能化支架将代表该领域的突破，并将通过降低与医疗设备相关的感染率和改善囊性纤维化患者的气道清除率产生深远的影响。

Bacterial biofilms are a major problem in healthcare systems around the world as they cause persistent and chronic infections, including those associated with medical implants and cystic fibrosis. This project aims to develop new chemical approaches to deliver nitroxides at surface interfaces and in microparticles to facilitate long term control over biofilm growth. It is expected that these functionalised scaffolds will represent a breakthrough in the field and will have a profound impact by reducing infection rates associated with medical devices and improving airway clearance in cystic fibrosis patients.