PCR analysis herpes simplex virus brainstem and myelitis

我们分析了1993-1995年在日本九州和冲绳进行的一项调查中发现的39例中枢神经系统（CNS）单纯疱疹病毒（HSV）感染患者的数据。并进行巢式聚合酶链反应（PCR）和酶免疫吸附试验（EIA）。颞叶边缘脑炎分为播散性脑脊髓炎（ADEM）（3例）、脑膜炎（2例）、弥漫性脑炎（2例）、脑干型（1例）和其他（5例）。我们的研究中还有复发型（2例）和延长型（11例）住院超过6个月。自PCR诱导以来，本研究明确了HSV CNS感染包括更广泛的形式，如HSV相关的ADEM、脑干脑炎、脊髓炎和脑膜炎。HSV 1和HSV 2分化的PCR EIA分析包括少数HSV 2感染患者。非疱疹性急性边缘脑炎2例。这些数据与我们之前在1990-1992年对同一地区进行的研究进行了比较。

We analyzed data from 39 patients with herpes simplex virus (HSV) infections of central nervous system (CNS) found in a 1993-1995 survey in Kyushu and Okinawa, Japan. Additionally nested polymerase chain reaction (PCR) analysis and enzyme immunosorbent assay (EIA) were conducted. Temporal lobe-limbic encephalitis was disseminated encephalomyelitis (ADEM) (3), meningitis (2), diffuse encephalitis (2), brainstem type (1) and other (5). There were also recurrent type (2 patients) and prolonged cases (11) hospitalized over 6 months in our study.Since the induction of PCR , this study clarified that HSV CNS infections consisted of wider forms such as HSV related ADEM, brainstem encephalitis, myelitis and meningitis. PCR EIA analysis of HSV 1 and 2 differentiation included a few patients with HSV 2 infections. Also, 2 patients with non-herpetic acute limbic encephalitis were found. These data are compared with our previous study performed same regions in 1990-1992.