Study on Biofunctional Restorative Material with Pulpal Cell

本项目的主要任务是进行牙髓细胞生物功能修复材料的研究，该项目由加州大学旧金山分校口腔修复学系和新泻大学牙科学院牙科手术与牙髓学系联合资助，由蒙布霍(教育部)国际科学研究计划--大学-大学合作研究资助，为期3年。2)与牙髓有关的研究：正常牙齿牙髓功能的细胞生物学和免疫组织化学研究，以及牙髓对各种外界刺激的反应。3)与牙科材料有关的研究：各种粘结牙科材料的氟化物释放，人牙釉质和牙本质从材料中摄取氟化物，以及它对耐酸性的影响。

This project undertaken to perform 「Study on Biofunctional Restorative Material with Pulpal cell」, was funded in part by a 3-year grant in aid from the Monbusho (Ministry of Education) International Scientific Research Program -University- to University Cooperative Research, as a joint effort between the Department of Restorative Dentistry, University of California, San Francisco, School of Dentistry and the Department of Operative Dentistry and Endodontics, Niigata University Faculty of Dentistry.This study consists of the following three parts.1) Research concerning with the human dentin : the ultra-microstructure of the human sound and carious dentin, dentin demineralization, the dentin substrate, and human dentin and the dentin resin adhesive interface.2) Research concerning with the dental pulp : the cell-biological and immunohistochemical studies on the pulpal function of normal teeth, and the reaction of dental pulp to the various external irritations.3) Research concerning with the dental materials : fluoride release from the various adhesive dental materials, fluoride uptake by human enamel and dentin from materials, and its effect to acid resistance.