Anthhropological and genetic studies on ocular inflammatory diseases in Mongoloids

这是众所周知的，因为某些可感染性炎症性疾病只发生在蒙古族人口中。我们主要研究Vogt-Koyanagi-Harada病和Behcet病中的流行病学、临床特征、医学人类学和分子遗传学，据报道，Vogt-Koyanagi-Harada病已在东亚国家、中亚国家、北美和南美洲发现。在相反的情况下，在高加索人中，这种疾病很少被发现，Vogt-Koyanagi-Harada病在澳大利亚的阿伯里吉尼人经常出现，可能在巴布亚新几内亚人口中。由于这种疾病与HLA-DRB 1-DRB 1-D104在东亚患者中密切相关，如果在其他人群中发现相同的HLA关联，这对进一步的研究是很重要的。在Behcet的疾病中，在东亚国家没有发现患者。这种疾病主要是沿着丝绸之路发现的，如韩国、中国、伊朗、土耳其和摩洛哥。在这些国家，新案件的数量仍然在增加，而且还需要更多的流行病学研究来调查这一可能的原因。在1998年的一项调查中，我们看到了蒙古贝塞特病患者。这是对世界的第一份报告。我们已经完成了对Behcet疾病中希腊患者的分子遗传学的分析。HLA-B-D-15101的频率为81.1%，明显高于正常的希腊控制。MICA-A6，HLA地区附近的微卫星警报之一，也与这种疾病有明显关联。这是很有趣的发现日本患者和希腊患者与Behcet的疾病之间的相同HLA关联，我们从伊朗和土耳其的Behcet的典型患者身上成功地获得了血液样本。这是意料之中的，我们也可以从摩洛哥得到样品。进一步的HLA-DNA分析将在未来进行。

It is well known that certain intractable inflammatory ocular diseases occur only in Mongoloid population. We have been studying the epidemiology, clinical feature, medical anthropology, and molecular genetics in mainly Vogt-Koyanagi-Harada disease and Behcet's disease.It was revealed that Vogt-Koyanagi-Harada disease was found in East Asian countries, Central Asian countries, North America and South America. In contrast, in Caucasians, this disease was rarely found. Vogt-Koyanagi-Harada disease was frequently seen in Australian Aborigini people, and possibly, in Papua New Guinean population. Since this disease is strongly associated with HLA-DRB1ィイD1*ィエD104 in East Asian patients, it is important to further study if the same HLA association is found in other populations.In Behcet's disease, no patients were found in East Asian countries. This disease was mainly found along the Silk Road, such as Korea, China, Iran, Turkey, and Morocco. In these countries, the number of new cases is still increasing and further epidemiological studies are needed to investigate the possible cause for this. In 1998's investigation we saw patients with Behcet's disease in Mongolia. This is the first report of the world. We have finished analyzing the molecular genetics of Greek patients with Behcet's disease. The frequency of HLA-BィイD1*ィエD15101 was 81.1 %, significantly higher than the healthy normal Greek controls. MICA-A6, one of the microsatellite alleles near the HLA region, was also significantly associated with this disease. It was interesting to find the same HLA association between Japanese and Greek patients with Behcet's disease.We have successfully gotten the blood samples from typical patients with Behcet's disease in Iran and Turkey. And it is expected that we could also get the samples from Morocco. Further HLA-DNA analyses will be performed in the near future.