Study on epidemiology of the chronic arsenic poisoning in China

目前全球范围内发生的大规模慢性砷中毒是由井水中的无机砷污染造成的。他们大约有1300万人，印度有1000万人，据推测中国有200万人，而慢性砷中毒的症状迟早出现在高浓度接触无机砷的总人数的20%左右。本研究以内蒙古地区和山西地区为调查对象。本研究中的产品是以下提到的结果。慢性砷中毒的原因是井水中含有的一种砷酸盐。井水平均推定一天的砷摄入量表明，达到约1毫克和约3毫克的机会经常存在。慢性砷中毒患者对肝脏中的一种砷酸盐进行了解毒(两个阶段的甲基化)。微量无机Ar-…慢性砷中毒的皮肤表现高浓度无机砷暴露(井水中As浓度为0.05~1ppm)有依次为颈白质漂白、色素沉着、腹部手足背部砷角化的倾向。高浓度无机砷暴露(1~3ppm)慢性砷中毒皮肤表现确诊1例，其出现或先于着色物漂白和色素沉着型砷角化病同时存在。与女性相比，慢性砷中毒男性的皮肤表现更为严重。皮肤表现存在性别差异，观察到无机砷暴露，20年内未观察到致癌性。DNA损伤物质(尿-8-羟基-2-鸟苷)的测定可有效地评估因接触无机砷而导致尿液致癌的风险。慢性砷中毒患者经0.05ppm及以下饮用水排泄，体内砷快速排出。阐明了预防和改善慢性砷中毒的可能途径。具体来说，使用0.05ppm或以下的饮用水对砷角化病的改善是明确的。较少

Large-scale with the chronic arsenic poisoning is generated by the inorganic arsenic contamination of the well water now globally. They are about 13,000,000 people, India is 10,000,000 people, and it is guessed that China is 2,000,000 people, and the symptom of the chronic arsenic poisoning appears about 20% sooner or later the total of high concentration those who expose inorganic arsenic. The region of this research for the investigation in Inner Mongolia and Shanxi Province. The products in this research is the under mentioned results. The cause of the chronic arsenic poisoning is an arsenate, which the well water contains. The amount of the arsenic intake of average presumption from the well water during a day clarified that the chance to reach about 1mg and about 3mg existed frequently. The chronic arsenic poisoning patient had the detoxification (methylate of two stages) for an arsenate in the liver. The skin manifestation of the chronic arsenic poisoning by a slight inorganic ar … More senic exposure (As concentrations is 0.05-1 ppm in well water) had the tendency admitted in order of the arsenical keratosis of the collaring matter bleaching, the pigmentation, and the hand and the foot of the abdomen in the back.The skin manifestation of the chronic arsenic poisoning from a high concentration inorganic arsenic exposure (for 1-3 ppm) confirmed a case, which appeared or was preceding at the same time as the coloring matter bleaching and the pigmentation arsenical keratosis existed. Man's skin manifestation in the chronic arsenic poisoning was a serious illness compared with the woman. The difference of the sex difference existed in the skin manifestation.The inorganic arsenic exposure was observed and carcinogenecity was not observed for less than 20 years. The measurement of the DNA damage material (urinary-8-hydroxyl-2-guanosine) was effective for the risk evaluation of carcinogenecity in urine because of the inorganic as exposure. The chronic arsenic poisoning patient was excreted and the arsenic was excreted from inside the body rapidly by using the drinking water of 0.05ppm or less. Possible prevention and the improvement of the chronic arsenic poisoning were clarified. Concretely, the arsenic-keratosis clarified the improvement by using the drinking water of 0.05ppm or less. Less