Development of Unprecedented Aluminosilicate Adjuvants

高性能佐剂是疫苗技术的重要组成部分。基于氯霉素的佐剂被广泛使用，但提供弱的细胞免疫和可能的神经毒性风险。结合最先进的纳米技术和经典的配位化学，该项目旨在应用一种新的设计原理来创造新型的具有碱性的介孔硅铝酸盐纳米颗粒，用作纳米佐剂。该项目预计将推进免疫系统如何响应铝硅酸盐材料的化学和纳米结构变化的知识，并使纳米佐剂的设计具有增强的细胞免疫力和降低的毒性。结果包括一个新的功能材料家族，具有前所未有的佐剂性能。

High-performance adjuvants are essential components of vaccine technology. Aluminium-based adjuvants are widely used, but provide weak cellular immunity and possible risk of neurotoxicity. Combining state-of-the-art nanotechnology and classic coordination chemistry, this project aims to apply a new design principle to create novel mesoporous aluminosilicate nanoparticles with alkalinity, for use as nanoadjuvants. This project expects to advance knowledge of how immune systems respond to changes in chemistry and nanostructure of aluminosilicate materials and enable the design of nanoadjuvants with enhanced cellular immunity and reduced toxicity. Outcomes include a new family of functional materials with unprecedented adjuvant performance.