ENHANCING THE INTERNATIONAL MOLECULAR EXCHANGE (IMEX): PROVIDING AN IMPROVED COMMUNITY-ORIENTED MOLECULAR INTERACTIONS RESOURCE

项目摘要 IMEx联盟（http：//www.imexconsortium.org/）是一个主要公共部门之间的国际合作组织。 交互数据提供器，通过文献整理和实验台沉积捕获实验数据 科学家IMEx成员数据库使用中央注册表共享和协调其策展工作 （IMExCentral：https：//imexcentral.org/icentral/）来管理文章的选择， 非冗余的，一致注释的蛋白质相互作用的集合。与其他当前活跃的互动相比， 数据库，IMEx策展人遵循详细的策展模型，捕捉实验方法的信息 以及生物学上重要的细节，如必需的结合区域和翻译后修饰， 突变及其对蛋白质相互作用的影响。这允许下游用户分析蛋白质相互作用 网络及其在正常和疾病状态下的调节。 在本提案中，我们寻求支持继续和扩大IMEx与策展有关的活动。 以及提供特别强调人类交互组的交互数据。未来五年，我们将 (1)通过从至少4000个新出版物中收集信息来扩充IMEx交互数据集， 数以万计的人类蛋白质相互作用;（2）传播新的和现有的IMEx相互作用记录 通过一个新的，联盟范围的IMEx蛋白质相互作用资源，其中将包括一个互动的网站， 符合标准的PSICQUIC Web服务和FTP下载站点（将 提供给我们的长期合作者，Reactome，UniProtKB和GO Consortium）;（3）提供培训， 现有的和新的用户社区使用蛋白质相互作用数据和网络分析癌症相关的 大数据。

Project Summary The IMEx Consortium (http://www.imexconsortium.org/) is an international collaboration between major public interaction data providers which captures experimental data through literature curation and deposition by bench scientists. IMEx member databases share and coordinate their curation efforts, using a central registry (IMExCentral: https://imexcentral.org/icentral/) to manage the selection of articles in order to provide a single, non-redundant, consistently-annotated set of protein interactions. In contrast to other currently active interaction databases, IMEx curators follow a detailed curation model which captures information on experimental methods and biologically important details such as essential binding regions and post-translational modifications, as well as mutations and their effect on protein interactions. This allows downstream users to analyze protein interaction networks and their regulation in normal and disease states. In this proposal we seek support for the continuation and extension of IMEx activities related to the curation and provision of interaction data with special emphasis on human interactome. Over the next five years, we will (1) augment the IMEx interaction dataset by curating information from at least 4000 new publications, providing tens of thousands of human protein interactions; (2) disseminate new and existing IMEx interaction records through a new, consortium-wide IMEx Protein Interaction Resource, which will include an interactive web site, a standards-compliant PSICQUIC web-service and ftp download site (customized subsets of the data will be provided to our long term collaborators, Reactome, UniProtKB and GO Consortium); (3) provide training for existing and new user communities on the use of protein interaction data and network analysis of cancer-related `big data'.