Viral Pathogenesis and Evolution Training Program (VPETP)

项目总结/摘要 病毒感染和疾病仍然是一个主要的全球健康问题，因此，我们必须支持 培养训练有素的科学家，他们准备领导病毒传播和发病机制的研究。的 Fred哈钦森癌症研究中心（Fred Hutch）和华盛顿大学（UW）有着悠久的历史 在过去的五年里，我们还大大扩展了我们在病毒发病机制研究方面的专业知识， 病毒进化研究十年前，我们创建了一个病毒发病机制培训计划， 在弗雷德·哈奇和华盛顿大学实验室从事病毒发病机制研究的受训人员的伞式计划。 认识到研究病毒进化以更好地理解和预测病毒的重要性， 流行病，我们建议在这里扩大我们的计划的重点，包括病毒的进化和计算 病毒研究-病毒发病机制和进化培训方案。因为博士预科 从事病毒发病机制和进化研究的学生分散在各种研究生中， 项目和实验室在弗雷德哈奇和华盛顿大学，这个计划是必不可少的，以创造一个有凝聚力的， 互动培训计划，汇集了所有这些学生，提供增强的机会，超越 这些都是由他们特定的研究生课程提供的。参与本培训计划的实验室研究了 各种各样的病毒感染，包括作为全球主要威胁的病毒，如DENV，埃博拉病毒，艾滋病毒， 流感和寨卡病毒以及致癌（HCV，KHSV，HPV，MCPyV）和机会性（HSV，CMV，AdV） 病原体参与实验室研究的病毒的多样性将增加该计划的广度， 在所有参与实验室中保持对病毒引起的疾病的总体关注。学员人数 VPETP将从几个现有的研究生课程中抽取，这些课程将病毒学培训作为一个领域， 着重将使用计算方法研究病毒的实验室包括在内， 我们的学生有机会学习对下一代科学家至关重要的计算技能。 该培训计划的特点将包括共同的教学培训以及机会， 学生和教师之间的演示和其他互动。这个共同的焦点将创造一个保护伞 为学生的这种培训补助金，是不同于现有的部门或计划结构。病毒 发病机制和进化培训补助金是西雅图唯一一个专注于病毒研究的培训补助金 或特别是病毒发病机理和进化。

PROJECT SUMMARY/ABSTRACT Viral infection and disease continue to be a major global health issue and thus it is critical that we support the development of well-trained scientists who are poised to lead studies of viral spread and pathogenesis. The Fred Hutchinson Cancer Research Center (Fred Hutch) and University of Washington (UW) have a rich history of research in viral pathogenesis and over the past five years, we have also greatly expanded our expertise in viral evolution research. Ten years ago, we created a Viral Pathogenesis Training Program to provide an umbrella program for trainees pursuing research in viral pathogenesis in laboratories at Fred Hutch and UW. In recognition of the importance of studying the evolution of viruses to better understand and anticipate viral epidemics, we propose here to expand the focus of our program to include viral evolution and computational studies of viruses – the Viral Pathogenesis and Evolution Training Program (VPETP). Because predoctoral students pursing studies of viral pathogenesis and evolution are dispersed among a variety of graduate programs and laboratories at Fred Hutch and UW, this program is essential to create a cohesive and interactive training program that brings together all of these students to provide enhanced opportunities beyond those provided by their specific graduate program. The labs participating in this training program study a diverse array of viral infections, including viruses that are major global threats such as DENV, Ebola, HIV, Influenza, and Zika as well as oncogenic (HCV, KHSV, HPV, MCPyV) and opportunistic (HSV, CMV, AdV) pathogens. The diversity in the viruses studied among participating labs will add breadth to the program, while maintaining an overarching focus on virus-induced diseases among all the participating labs. Trainees for the VPETP will be drawn from several existing graduate programs that have training in virology as one area of emphasis. The inclusion of laboratories using computational approaches to the study of viruses will provide opportunities for our students to learn computational skills that are critical for the next generation of scientists. Features of this training program will include common didactic training as well as opportunities for presentations and other interactions among students and faculty. This common focus will create an umbrella for the students of this training grant that is distinct from existing departmental or program structures. The Viral Pathogenesis and Evolution Training Grant is the only training grant in Seattle that is focused on virus research in general or viral pathogenesis and evolution in particular.