Predoctoral Training in the Pharmacological Sciences

项目总结/摘要 这是第三个竞争更新申请的培训计划，其主要目标是促进 药理学研究生的跨学科培训。它的第二个目标是培养 在药理学科学的教师和学生之间更广泛的科学和社会互动。 作为该计划的跨学科性质的证据，我们的学员来自六个部门和四个 三所大学的跨部门研究生课程。招聘了37名具有较强适应能力的培训生， 来自药理学系外的优秀证书（共50份）是切实的证据 这个TG作为一个非常有效的机制，以吸引兴趣，促进跨学科 药理学研究生的培训，无论部门隶属关系。 TG课程提供药理学科学的基础和高级指导， 不断检讨和修订，以确保它符合程序和学生的需要。其 核心课程序列，药理学和药物遗传学与药物基因组学原理，暴露 学员的药物作用的基本原则，以及主要的分子和细胞作用机制， 毒品课该计划的旗舰课程，药理学科学高级问题解决 为学员提供多种机会，作为一个团队设计合作研究计划，从而 磨练他们交流科学思想和为当代问题提供可行解决方案的能力 在药理学科学。两个模块是新的课程。基础生物统计学和实验 设计是该计划对NIH要求提高科学严谨性和可重复性的回应。科学 数字时代的通信和相关研讨会学院以外的职业：科学 沟通拓宽了职业技能的传授，使我们的学员为就业市场做好更好的准备。 研讨会，一年两次的务虚会，一系列夏季棕色袋子讨论午餐会，以及半 药理学研讨会期间的每周互动进一步促进了项目认同和合作。 这个TG导致了有记录的教学，指导和研究之间的互动增加 项目教师和学生。随着我们研究基础设施的不断扩大， 课程，包括非学术职业的技能建设，以及一个强大的机构和方案 致力于STEM少数民族教育，该计划处于有利地位，有资格获得额外的 五年融资。因为我们通常有超过两倍的高素质申请人 由于我们的机构缺乏培训补助金支持，我们要求 职位数目从6个增加到7个。我们的TG的这种适度扩展是合理的：1） 我们的申请人库的质量和规模，2）我们的实习生库的多样性（24% URM，48%女性），以及大多数 最重要的是，3）我们毕业生的生产力和成功。

Project Summary / Abstract This is the third competing renewal application for a training program whose main goal is to promote the interdisciplinary training of graduate students in Pharmacological Sciences. Its secondary goal is to foster broader scientific and social interactions among faculty and students in the Pharmacological Sciences. As evidence of the interdisciplinary nature of this program, our trainees come from six departments and four interdepartmental graduate programs in three colleges. The recruitment of 37 trainees with strong-to- outstanding credentials from outside the Department of Pharmacology (of a total of 50) is tangible evidence that this TG functions as a highly effective mechanism to attract the interest and promote the interdisciplinary training of graduate students in the Pharmacological Sciences regardless of departmental affiliation. The TG curriculum provides both basic and advanced instruction in Pharmacological Sciences, and is undergoing continual review and revision to ensure that it fulfills the needs of the program and the students. Its core course sequence, Principles of Pharmacology and Pharmacogenetics & Pharmacogenomics, exposes trainees to the fundamental principles of drug action, and molecular and cellular mechanisms of action of major drug classes. The flagship course of this program, Advanced Problem Solving in Pharmacological Sciences provides trainees multiple opportunities to work as a team to design collaborative research plans, thereby honing their ability to communicate scientific ideas and generate workable solutions to contemporary problems in the Pharmacological Sciences. Two modules are new to the curriculum. Basic Biostatistics and Experimental Design is the program's response to NIH's call for enhanced rigor and reproducibility in science. Science Communication in the Digital Age and the associated workshop Careers outside the Academy: Science Communication broaden the delivery of career skills to better prepare our trainees for the job market. Symposia, a bi-annual retreat, a series of summer-time brown bag discussion luncheons, as well as semi- weekly interactions during Pharmacology Seminar further promote program identity and collaborations. This TG has led to a documented increase in the teaching, mentoring and research interactions among program faculty and their students. With the continued expansion of our research infrastructure, an adaptive curriculum that includes skill building for non-academic careers, and a strong institutional and programmatic commitment to STEM education for minorities, the program is strongly positioned to qualify for an additional five years of funding. Because we typically have more than twice the number of highly qualified applicants than available slots and because our institution is underserved with training grant support, we are requesting an increase in the number of positions from 6 to 7. This modest expansion of our TG is justified by 1) the quality and size of our applicant pool, 2) the diversity of our trainee pool (24% URMs, 48% women), and most importantly, 3) the productivity and success of our graduates.