Biostatistics Shared Resource

生物统计共享资源(BSR)是一个集中式资源，它提供最先进的生物统计 为西蒙斯综合癌症中心(SCCC)开展癌症研究的研究人员提供支持。 生物技术和计算硬件/软件的进步极大地增加了对 复杂的统计方法，生物统计是确保高质量的必不可少的组成部分 癌症研究，特别是临床和转译研究。BSR生物统计学家发挥重要的综合作用 在每个SCCC研究项目中扮演的角色。这些富有成效的协作的格式包括 获奖项目和临床试验开发以及获奖后以项目为导向的统计服务。SCCC 研究涵盖了翻译管道的所有领域，从基础科学实验， 生物标记物研究，研究人员发起的新治疗剂和程序的临床试验，以满足人群- 基础研究。BSR教职员工还提供研讨会、办公室咨询、研讨会和学习课程。 面向研究员、研究人员和教职员工的设计、分析方法和软件实现。BSR是由 作者：Chul Ahn博士，一位著名的生物统计学家，以其统计而享誉全国和国际 设计和分析癌症研究和癌症临床试验。BSR生物统计学家也做出了重要贡献 SCCC议定书审查和监测委员会(PRMC)以及数据和安全监测委员会成员 该委员会提供了宝贵的独立统计资料。业务流程重组目前包括以下工作 5名生物统计师和3名分析员，提供各级生物统计学支持。该公司的服务 2014-2019年，在SCCC的五个研究计划中，有178名成员使用了BSR，并提供了关键 支持68项新的与癌症有关的外部资助赠款、96项癌症临床研究的数据和见解 试验和267篇同行评议的出版物，包括发表在《美国医学会杂志》、《华尔街日报》等顶级期刊上的研究成果 临床肿瘤学、美国医学会肿瘤学、柳叶刀肿瘤学、癌症发现、癌症、自然遗传学和 大自然。下一个供资期间的目标包括招聘更多的生物统计员，以加强在 适应性试验设计。

The Biostatistics Shared Resource (BSR) is a centralized resource that provides state-of-the-art biostatistical support for investigators conducting cancer research at Simmons Comprehensive Cancer Center (SCCC). Advances in biotechnologies and computing hardware/software have greatly increased the need for sophisticated statistical methodologies, and biostatistics is an essential component in ensuring high-quality cancer research, particularly in clinical and translational research. BSR biostatisticians play important integrated roles in each of the SCCC Research Programs. The formats of these productive collaborations include pre- award project and clinical trial development as well as post-award, project-oriented statistical services. SCCC research covers the full spectrum of the translational pipeline, ranging from basic science experiments, biomarker studies, investigator-initiated clinical trials of novel therapeutic agents and procedures, to population- based studies. The BSR faculty also offers workshops, office consultations, seminars, and courses on study design, analysis methods, and software implementation to fellows, research staff, and faculty. The BSR is led by Chul Ahn, PhD, a distinguished biostatistician with a national and international reputation for his statistical designs and analyses of cancer research and cancer clinical trials. BSR biostatisticians are also key contributing members of SCCC’s Protocol Review and Monitoring Committee (PRMC) and Data and Safety Monitoring Committee (DSMC), providing valuable independent statistical input. The BSR currently consists of efforts from five faculty biostatisticians and three analysts, providing all levels of biostatistics support. The services of the BSR were utilized by 178 members across five SCCC research programs from 2014-2019 and provided key data and insights to support the success of 68 new cancer-related extramurally funded grants, 96 cancer clinical trials, and 267 peer-reviewed publications, including work published in top tier journals such as JAMA, Journal of Clinical Oncology, JAMA Oncology, Lancet Oncology, Cancer Discovery, Cancer, Nature Genetics, and Nature. Goals for the next funding period include recruiting additional biostatisticians to strengthen expertise in adaptive trial design.