Core-007

此可选功能应用程序直接解决了UMCCTS的主要目标，具体而言， 将基本发现转化为改善人类健康的有效解决方案。我们将利用 麻省大学作为非编码RNA研究和发现中心的国际声誉， 集成生物标志物中心（InBioC），通过提供一个 加强临床研究的资源，丰富生物标志物创新，促进新的发现，并建立 在更广泛的马萨诸塞州社区的桥梁。我们期待着扩大新颖，创新， 向更广泛的受众提供生物标志物将促进关于人类疾病的发现。目前 UMMS高通量基因表达/生物标志物实验室提供快速，具有成本效益的生物标志物 分析和生成各种项目的宝贵数据。重要的是，实验室不是静态的， 所使用的技术不断发展，以保持尖端和科学影响力。我们提供了一些 目前，我们正在研究人类群体中最大的非编码RNA数据集，并继续在这一领域开发新的工具。 利用这些专业知识，我们将把实验室建成一个中心枢纽，提供教育， 实验室和虚拟数据的基础上，他们的科学需求麻省大学的研究人员。形成这些中央 “连接”，综合生物标志物中心（InBioC），将通过以下方式连接数据和组： 生物标记物发展的科学。我们将与调查人员合作， 支持性数据，如蛋白质组学、RNA和表型信息。InBioC将1A。继续开发 尖端平台; 1b.设立“种子资金”计划，为调查人员提供支持， 生成用于方案、赠款和项目（上文讨论的）所需的数据; 1c.提供教育， 产生的数据和使用的技术，以及初级研究人员的实验室实习;和1d. 创建一个虚拟数据存储库，允许数据共享和/或重新分析。目标2：便利使用 生物标志物，以了解疾病和开发新的疗法：这将通过以下方式实现：2a.密切 与UMCCTS信息组件和UMCCTS BERD合作，支持和协助目标 根据新的和现有的数据集进行分析和网络开发。这将确保适当和 对通常复杂的信息进行有效的解释; 2b.与生物标志物开发密切合作， 特别是与UMCCTS组织核心和生物储存库，这将作为生物材料的来源， 调查员;和2C.与社区的联系和密切合作，科学参与 研究中心（SPRC）和5个麻省大学校园。

This Optional Function Application directly addresses a major goal of the UMCCTS, specifically, to accelerate the translation of basic discoveries into efficient solutions that improve human health. We will capitalize on UMass’ international reputation as a hub for noncoding RNA investigation and discovery to establish an Integrative Biomarker Center (InBioC), that builds onto existing UMCCTS infrastructure by providing a resource that enhances clinical research, enriches biomarker innovation, facilitates novel discovery, and builds bridges throughout the broader UMass community. We expect that the expansion of novel, innovative, and accessible biomarkers to a wider audience will enhance discoveries regarding human disease. Currently, the UMMS High-Throughput Gene Expression/Biomarker Laboratory provides rapid, cost-effective biomarker analyses and generates valuable data for a wide range of projects. Importantly, the lab is not static, and technologies utilized evolve to remain cutting edge and scientifically impactful. We have provided some of the largest data sets of noncoding RNAs in human populations and continue to develop novel tools in this area. Utilizing this expertise, we will build out the laboratory as a central hub that will provide education, as well as laboratory and virtual data to UMass investigators based on their scientific needs. To form these central “connections”, the Integrative Biomarker Center (InBioC), will link data and groups through: Aim 1: Advance the science of biomarker development. We will work with investigators to provide relevant and timely supportive data such as proteomics, RNA, and phenotypic information. InBioC will 1a. Continue development of cutting-edge platforms; 1b. Institute a “Seed Money” program to provide support for investigators to generate needed data for programs, grants, and projects (discussed above); 1c. Provide education regarding the data generated and technologies used, as well as in-laboratory internships for junior investigators; and 1d. Create a virtual data repository that will allow data sharing and/or reanalysis. Aim 2: Facilitate the use of biomarkers to understand disease and develop new therapies: This will be accomplished by: 2a. Close collaboration with UMCCTS Informatics Component and UMCCTS BERD to support and assist with target analyses and network development based on new and available data sets. This will ensure proper and productive interpretation of often complex information; 2b. Close collaboration with biomarker development, specifically with the UMCCTS Tissue Core and Biorepository, which will serve as a source of biomaterials for investigators; and 2c. Outreach and close collaboration with the community, the Science Participation Research Center (SPRC), and the 5 UMass Campuses.