TRIUX neo MEG system Upgrade

项目摘要/摘要 此应用程序寻求ORIP高端仪器(HEI)赠款计划的支持，以资助一项 Triux Neo Meg系统将用于阿蒂努拉·A·马蒂诺斯中心的基础/临床/翻译研究 用于生物医学成像。该系统将取代我们现有的已有20年历史的Vectorview系统，并将提供 马蒂诺斯中心广泛研究的业绩大幅提高：精神病学和 基础神经科学研究，神经和精神疾病的临床研究，癫痫的临床研究 抽动症患者，以及新型仪器和分析工具的开发。而脑磁图 马蒂诺斯中心的脑磁图(MEG)研究项目非常成功，我们的MEG系统于2001年安装， 已经走到了生命周期的尽头。服务由制造商保证只有一年：有一个 当然需要升级现有的系统。拟议的升级不仅将取代我们现有的MEG 系统，但将提供新的功能，以提高性能和数据质量：(I)仪器噪声水平 新的“盔甲”传感器更低，这将有利于对大脑深层结构和小脑的研究，因为 以及对自发性大脑活动的总体研究。(Ii)新系统的传感器非常稳定， 健壮，这保证了在睡眠研究和复杂的长时间记录中统一的高数据质量 认知实验。(Iii)新系统配备了新的脑电硬件，以促进高质量 脑磁图/脑电综合数据的记录。(4)新系统可以仰卧、直立和仰卧方式操作 体位，这为实验设计和受试者/患者舒适度提供了更多选择。(五)制度是 配备闭路氦气回收系统，减少停机时间，节省有限的氦气回收 资源，并降低运营成本。此外，Megin即将推出新的采集软件， 使该系统更加用户友好，面向临床和转化性研究。系统将 成为独一无二的仪器仪表和软件开发的最新测试平台和比较平台 在马蒂诺斯中心工作，包括实时处理脑磁图/脑电数据，创建新的检测工具 分析来自新大脑皮层以外的大脑结构的信号，以及开发新的设备和系统- TEMS，它将使用新的传感器，实现头皮脑磁图测量，以补充经过验证的功能 基于鱿鱼的健壮技术。这项开发工作的成果将免费分发给 脑磁图/脑电图社群普遍存在。通过为PHS资助的高生产率跨学科调查小组提供服务- Tors，这一拟议的升级将增强现有的研究计划，同时促进机会- 为新项目和协作的出现和蓬勃发展创造条件。因此，此次升级将有助于为 其他由PHS资助的研究中心将以最佳方式使用当前和下一代MEG技术， 进一步帮助证明脑磁图临床应用的实用性和重要性，并将为我们的研究人员提供 具有创新的基础和转化研究以及临床研究所需的技术优势。

Project Summary / Abstract This application seeks support from the ORIP High-End Instrumentation (HEI) Grant program to fund a MEGIN Triux Neo MEG system to be used for basic/clinical/translational research at the Athinoula A. Martinos Center for Biomedical Imaging. This system will replace our existing, 20-year-old Vectorview system, and will provide an substantial increase of performance for the wide range of research at the Martinos Center: psychiatric and basic neuroscience studies, clinical research on neurological and psychiatric diseases, clinical studies of epilep- tic patients, and development of novel instrumentation and analytical tools. While the Magnetoencephalography (MEG) research program at the Martinos Center has been very successful, our MEG system, installed in 2001, has come to the end of its life cycle. Service is guaranteed by the manufacturer only for another year: there is a definite need to upgrade the existing system. The proposed upgrade will not merely replace our existing MEG system but will offer new features for improved performance and data quality: (i) The instrumental noise level of the new “ARMOR” sensors is lower, which will benefit studies of deep brain structures and the cerebellum as well as studies of spontaneous brain activity in general. (ii) The sensors in the new system are very stable and robust, which guarantees uniform high data quality in long recordings in, e.g., sleep studies and in complex cognitive experiments. (iii) The new system is equipped with new EEG hardware, which facilitates high-quality recording of combined MEG/EEG data. (iv) The new system can be operated in supine, upright, and reclined positions, which provides more options for experimental design and subject/patient comfort. (v) The system is equipped with a closed-circuit helium reliquefication system, which reduces downtime, saves limited helium re- sources, and reduces operational costs. In addition, MEGIN is about to introduce new acquisition software, which makes the system more user friendly and is geared towards clinical and translational studies. The system will be an up-to-date testbed and comparison platform for the unique instrumentation and software development work at the Martinos Center, including real-time processing of MEG/EEG data, creation of new tools for detecting and analyzing signals from brain structures outside the neocortex, and development of new devices and sys- tems, which will use new sensors enabling on-scalp MEG measurements to complement the proven capabilities of the robust SQUID-based technology. The results of this development work will be freely disseminated to the MEG/EEG communities at large. By serving a highly productive interdisciplinary group of PHS-funded investiga- tors, this proposed upgrade will enhance existing research programs while at the same time fostering opportu- nities for new projects and collaborations to emerge and flourish. This upgrade will thus help pave the way for other PHS-funded research centers to optimally use both present and next-generation MEG technologies, will further help demonstrate the utility and importance of the clinical use of MEG, and will provide our investigators with a technological edge required for innovative basic and translational research, as well as for clinical studies.