Cancer Prevention and Control Research Program

癌症预防和控制程序-摘要 斯蒂芬森癌症中心(SCC)癌症预防和控制(CPC)计划的目标是 建立一个强有力的、跨学科的CPC研究和培训计划，以减轻 俄克拉荷马州(SCC集水区)，特别是在该州服务不足的人口中。该计划特定 目标是：1)进行社区参与的研究，以解决癌症不成比例的负担 影响SCC集水区的美洲印第安人(AI)、农村和其他服务不足的人口；2) 发现烟草启动、维持、戒烟和复发的机制，并发展 并评估针对弱势和服务不足人群的新型烟草治疗方法；以及3)发现， 开发和应用天然、合成和生物制剂来预防、逆转或抑制癌症 SCC集水区和全国高危人群的进展。 CPC计划的亮点包括：1)一个高度互动的癌症健康差异研究团队 他们与该州的人工智能和农村人口建立了基于信任的协作关系，领导着 NIH资助的基于社区的研究；2)一个非常成功的人工智能患者导航计划，它已经 促进1,554名AI患者(代表54个不同部落)获得专门的肿瘤学护理 过去五年的SCC；3)由NIH资助的烟草调查人员组成的日益壮大和高度合作的团队 他们正在进行广泛的烟草研究，从成瘾的基本机制到新的戒烟方式 干预措施和新兴烟草产品；4)国家认可的癌症化学预防小组 自2012年以来，得到了超过1200万美元的NCI资金(预防和其他)的支持；以及5)强大的CPC- 针对本科生和研究生、博士后研究员和大三学生的重点教育和培训计划 教职员工，并计划在两年内提交NIH机构培训补助金。 CPC项目有27名成员，代表11个部门和一系列跨学科的专业知识， 包括癌症健康差距、基于社区的参与性研究、护理协调和提供、 新的烟草预防和戒烟干预措施，新兴烟草产品，基本机制 毒瘾和癌症的化学预防。截至2016年12月31日，中共计划成员获得 5,575,776美元(36个项目)，每年用于NCI和其他同行审查的癌症相关资金(直接费用)。NCI 资金(2,637,717美元)占同行审查资金的近一半(47.3%)，突显了该项目的 癌症焦点。年度CPC计划资金总额为8,945,333美元(直接成本)。五年报告期 (2012-2016)，CPC计划成员发表了237篇同行评议文章，其中36.3%有 方案，5.9%有方案间的，64.1%有机构间的协作者。2016年，内部- 纲领性出版物占42.0%，突显了CPC项目研究的高度协作性。

CANCER PREVENTION AND CONTROL PROGRAM – ABSTRACT The goal of the Cancer Prevention and Control (CPC) program at the Stephenson Cancer Center (SCC) is to build a robust, transdisciplinary CPC research and training program in order to reduce the burden of cancer in Oklahoma (the SCC catchment area), especially in the state's underserved populations. The program Specific Aims are: 1) to conduct community-engaged research to address the disproportionate burden of cancer affecting American Indian (AI), rural and other underserved populations in the SCC catchment area; 2) to discover the mechanisms underlying tobacco initiation, maintenance, cessation and relapse, and to develop and evaluate novel tobacco treatments targeted to vulnerable and underserved populations; and 3) to discover, develop and apply natural, synthetic and biological agents to prevent, reverse or suppress cancer disease progression in high-risk cohorts in the SCC catchment area and the nation. Highlights of the CPC program include: 1) a highly interactive team of cancer health disparities researchers who have developed collaborative, trust-based relationships with the state's AI and rural populations, leading to NIH-funded community-based research; 2) a highly successful AI Patient Navigation Program that has facilitated access for 1,554 AI patients (representing 54 different tribes) to specialized oncology care at the SCC over the past five years; 3) a growing and highly collaborative team of NIH-funded tobacco investigators who are conducting a wide range of tobacco research, from basic mechanisms of addiction to novel cessation interventions and emerging tobacco products; 4) a nationally recognized cancer chemoprevention team supported by more than $12 million in NCI funding (PREVENT and other) since 2012; and 5) a robust CPC- focused education and training program for under- and graduate students, postdoctoral fellows and junior faculty, with plans for an NIH institutional training grant submission within two years. The CPC program has 27 members, representing 11 departments and a range of transdisciplinary expertise, including cancer health disparities, community-based participatory research, care coordination and delivery, novel interventions for tobacco prevention and cessation, emerging tobacco products, basic mechanisms of addiction and cancer chemoprevention. As of December 31, 2016, CPC program members were awarded $5,575,776 (36 projects) in annual NCI and other peer-reviewed cancer-relevant funding (direct cost). NCI funding ($2,637,717) accounts for nearly half (47.3%) of the peer-reviewed funding, highlighting the program's cancer focus. Total annual CPC program funding is $8,945,333 (direct cost). For the five-year reporting period (2012-2016), CPC program members published 237 peer-reviewed articles, of which 36.3% had intra- programmatic, 5.9% had inter-programmatic, and 64.1% had inter-institutional collaborators. For 2016, intra- programmatic publications were 42.0%, underscoring the highly collaborative nature of CPC program research.