Improving the Health of Aging Women and Men.

项目摘要/摘要 这是一份申请加州大学新机构T32国家研究服务奖的申请书 加州大学圣地亚哥分校(UCSD)旨在培养致力于 改善老年女性和男性的健康状况，了解性别差异。该计划的重点是 准备研究人员对影响生命过程中衰老的因素进行翻译研究 从中年到临终。重点是老年妇女的特别关注，因为 他们在一生中都面临着挑战。该项目将由Andrea Z.LaCroix博士、教授 和流行病学系主任，国际知名的资深“老年流行病学家”，有10年的经验 指导以前由NIA资助的T32项目的经验。她的领导伙伴是联席董事琳达·麦克沃伊， 博士，一位研究认知老化和脑成像风险因素的知名神经科学家和艾莉森 摩尔，医学博士，老年医学主任，拥有20年的NIH资金，并指导了50多名实习生。这个 该计划围绕6个主要研究领域组织：1)性别和性别差异的研究；2)早期生活 预测未来生活结果的因素(一个超越所有关注领域的领域)；3)更年期和中年；4)健康 精神和身体老化；5)慢性病、多种疾病和存活率；6)健康差距和 弱势群体。博士前实习生将从两个具有高度选择性的博士项目中招募 家庭医学和公共卫生系(FMPH)：1)加州大学圣地亚哥分校/圣地亚哥州立大学联合 公共卫生博士课程(JDP)，课程包括流行病学、全球健康和健康行为；以及 2)生物统计学博士项目。博士后学者将从全国博士后项目中招聘 公共卫生、预防医学、神经科学、心理学、营养学、理疗、运动科学、 人口学、药剂学和其他学科。T32计划的近期目标是确保 每个实习生：1)建立一个研究计划和大量已发表的关于老年妇女的研究 或男性的健康和/或性别差异是新的、重大的和作为未来基础的变革性差异 资助申请；2)培养他们的口头演示技能；3)获得详细的知识和策略 成功设定并达到职业发展里程碑；4)制定并提交拨款申请 适合他们的培训水平；5)完成培训，并在负责任的行为中应用知识 研究；以及6)成为加州大学圣地亚哥分校老龄化研究社区的有价值和有贡献的成员 全国范围内。计划主管将主持每周一次的T32研讨会，其中包括以下方面的结构化培训： 指导；从一个新的和有意义的研究问题的概念开始进行老龄化研究，以 纳入评估健康差距的严格方法，出版和传播；赠款撰写； 和职业发展。我们的长期目标是培养下一代跨学科的科学家 美国将拿出对老年男女健康有重大影响的证据。

Project Summary/Abstract This is an application for a new Institutional T32 National Research Service Award at the University of California, San Diego (UCSD) designed to train predoctoral and postdoctoral public health scientists devoted to improving the health of aging women and men and understanding sex differences. The program focuses on preparing researchers to conduct translational studies of factors affecting aging through the life course from middle-age to end of life. Emphasis is placed on special concerns of aging women due to the unique challenges they face across the life course. The program will be directed by Andrea Z. LaCroix, PhD, Professor and Chief of Epidemiology, who is an internationally known senior “aging epidemiologist” with 10 years of experience directing a prior NIA-funded T32 program. Her leadership partners are Co-Directors Linda McEvoy, PhD, an established neuroscientist who studies risk factors for cognitive aging and brain imaging and Alison Moore, MD, Chief of Geriatrics who has 20 years of NIH funding and has mentored more than 50 trainees. The program is organized around 6 major research areas: 1) the study of sex and gender differences; 2) early life predictors of later life outcomes (an area that transcends all focus areas); 3) menopause and midlife; 4) healthy aging in mind and body; 5) chronic disease, multiple morbidity and survivorship; and 6) health disparities and vulnerable populations. Predoctoral trainees will be recruited from two highly selective PhD programs in the Department of Family Medicine and Public Health (FMPH): 1) The UCSD/San Diego State University Joint Doctoral Program (JDP) in Public Health with tracks in Epidemiology, Global Health and Health Behavior; and 2) the PhD Program in Biostatistics. Postdoctoral scholars will be recruited from doctoral programs nationwide in public health, preventive medicine, neurosciences, psychology, nutrition, physical therapy, exercise science, demography, pharmacy, and other disciplines. The immediate goals of the T32 program are to ensure that each trainee: 1) establishes a research program and significant body of published research in aging women’s or men’s health and/or sex differences that is novel, significant and transformational as a foundation for future grant applications; 2) develops their oral presentation skills; 3) acquires detailed knowledge and strategies for success in setting and meeting career development milestones; 4) develops and submits a grant application appropriate to their level of training; 5) completes training and applies knowledge in the responsible conduct of research; and 6) becomes a valued and contributing member of the aging research community at UCSD and nationally. The Program Directors will host a weekly T32 Workshop that includes structured training in: mentorship; conducting aging research from conception of a novel and significant research question, to incorporating rigorous methods for evaluating health disparities, to publishing and dissemination; grant writing; and career development. Our long term goal is to build the next generation of interdisciplinary scientists across the US who will produce evidence that will have major impacts on the health of aging women and men.