Autoimmunity and Immunopathology Training Program

这是一个请求更新支持匹兹堡大学医学院（UPSOM）的培训 计划在自身免疫和免疫病理学（AI/IP），目前资助4个博士前和4个博士后- 实习生。AI/IP是一个核心的基础和应用研究领域，它带来了基础免疫学的见解， 以生物和机制为基础的疗法的形式对患者进行治疗。因此，我们的AI/IP培训计划 从免疫学相关领域的其他（成功的）培训计划中非常清楚地描述出来，例如 传染病或移植，在皮特。我们已经取得了成功：在忠实地执行我们的导师的同时- 根据计划，我们已经培训或正在培训22名博士生，20名不同的导师。13前- 博士生已经完成了他们的博士学位和两个完成了他们的MD/博士学位。这些学生 平均每篇发表论文5.8篇，平均第一作者论文2.5篇。我们的三位博士预科生 研究员是URM。大多数人继续从事研究密集型职业，无论是博士后还是工业。我们 我院还培养或正在培养21名博士后，导师19人，其中博士15人，博士3人 3个MD/PhD我们的三个博士后研究员是URM。我们的博士后培训生已经成功地在 以基金会奖学金和K奖的形式获得进一步的资助。我们实施了一项新的 课程，自身免疫和免疫病理学，沿着我们的“实习生日”活动，提供双向 反馈我们现在建议在现在已经证明的重要培训计划的基础上进行有意义的建设。 我们强调两个主要的改进：1）建立一个新的研究生课程。在Micro- 生物学和免疫学（PMI）成立于2017年，以加强重点免疫学和微生物学教育， 并加强这些相关领域之间的联系。PMI的建立，极大地促进了- 提高了我们申请人的质量和多样性，同时每年增加约6名学生。此外- 由于投资和招聘，我们的免疫学教师已经扩大，我们的培训教师已经 从28个增加到37个。我们已经增加了高质量的竞争，为我们的博士前职位， 因此，要求为这个周期增加一个博士前的位置; 2）建立系统研究中心， 免疫学该中心已经招聘了3名新教师，包括其主任Harinder Singh博士，并将 在这个关键的新兴领域提供尖端的研究和培训。我们的计划是在一个支持- 丰富的环境。UPSOM非常关心培训，并实施了一系列有效的培训计划。 计划，以确保在学生和博士后水平出色的培训。申请人的人数也 杰出的，鉴于我们成功的PMI和MSTP计划，我们备受追捧的临床奖学金， 我们的导师库对直接申请的研究员的吸引力。我们很高兴能执行我们的培训计划 为即将到来的周期，并利用我们已经取得的重大改进， 在培训机会和师资方面都有计划。我们认为前景是特殊的。

This is a request for renewal of support for the University of Pittsburgh School of Medicine’s (UPSOM) training program in Autoimmunity and Immunopathology (AI/IP), which currently funds 4 predoctoral and 4 postdoc- toral trainees. AI/IP is a central basic and applied research area that is bringing the insights of basic immu- nology to patients in the form of biological and mechanism-based therapies. Our AI/IP training program is thus very clearly delineated from other (successful) training programs in immunology-related areas, such as in infectious disease or transplantation, at Pitt. We have had success: while faithfully implementing our mentor- ing plan, we have trained or are training 22 pre-doctoral students with 20 different mentors. Thirteen pre- doctoral students have completed their PhD and two completed their MD/PhD degrees. These students have published an average of 5.8 papers each, with an average of 2.5 first author papers. Three of our pre-doctoral fellows are URM. Most are continuing in research-intensive careers, either as postdocs or in industry. We have also trained or are training 21 post-doctoral fellows with 19 different mentors, including 15 PhDs, 3 MDs and 3 MD/PhDs. Three of our post-doctoral fellows are URM. Our postdoctoral trainees have had success in obtaining further funding in the form of Foundation fellowships and K awards. We have implemented a new course, Autoimmunity and Immunopathology, along with our “Trainee Day” activities that provide bidirectional feedback. We now propose to build meaningfully on what is now a proven and important training program. We highlight two major enhancements: 1) Establishment of a new graduate program. The Program in Micro- biology and Immunology (PMI) was created in 2017 to enhance focused Immunology and Microbiology edu- cation and to strengthen the links between these related areas. The establishment of PMI has greatly in- creased the quality and diversity of our applicant pool, while adding about 6 additional students/year. In addi- tion, due to investment and recruitment our Immunology faculty has expanded, and our training faculty has increased to 37 from 28. We have had increased high-quality competition for our predoctoral slots and are thus requesting an additional pre-doctoral slot for this cycle; 2) Establishment of the Center for Systems Im- munology. This Center has already recruited 3 new faculty including its director Dr. Harinder Singh, and will provide cutting edge research and training in this key emerging field. Our program flourishes within a support- ive and rich environment. UPSOM cares deeply about training and has implemented a series of effective programs to ensure outstanding training at the student and postdoc levels. The pool of applicants is also outstanding, given our successful PMI and MSTP programs, our highly sought-after clinical fellowships, and the attractiveness of our mentor pool for fellows applying directly. We are excited to execute our training plan for the upcoming cycle, and to capitalize on the significant improvements that we have made and have planned both for training opportunities as well as in terms of faculty. We feel that the prospects are exceptional.