Pilot and Exploratory Studies Core

试点/探索性研究核心(PESC)的主要目标是促进创新研究的发展 和严谨的研究，将提高我们对病因、诊断、治疗和预防的了解 多因素老年病(耶鲁大学OAIC的重点)，最终导致 有效和成本效益高的干预措施，以增加或维持美国老年人的独立性。这个 PESC的领导人阿尔伯特·肖博士因其对人类免疫老化的研究而在全国范围内获得认可 系统。他拥有NIA颁发的专注于翻译免疫学的K24奖，他是 耶鲁大学传染病T32培训基金。自2004年以来，Shaw博士还领导了非常成功的 老龄化生物学系列研讨会，因此，他对耶鲁大学的老龄化研究有一个特别的概述。 Shaw博士将与PESC的联合负责人Terri Fry博士密切合作，Terri Fry博士是临床研究的领导者 患有多种疾病的老年人的决策。 PESC的具体目标是：(1)征集和遴选最有价值的研究建议 试点资金；(2)向试点/探索性研究(PESS)的调查人员提供从 业务(RC1)和生物统计(RC2)核心；(3)确定潜在的合作机会 PESC调查员；(4)监督PESS的进展；(5)提供协助，使PESS能够 成功开发为独立资助的赠款申请；及(6)确保安全和保护 加入PESS的人类受试者和脊椎动物。除了传统的一年期PESS外，我们还将 继续实施快速试点计划(EXI)，该计划将资助最多5000美元的小额赠款， 在申请后4周内获奖。这些资助是用于研究活动的，在这些活动中， 注入数额相对较少的资金将有助于成功地申请外部赠款。PESS和 博览会奖项将充分利用OAIC两个资源提供的资源和专业知识 核心。PESC的资金将优先考虑给初级调查人员以及职业生涯中期和 希望将他们的研究转向或扩大到多因素老年病研究的高级研究人员 条件。通过便利使用伊斯兰会议组织的研究基础设施，这些机制将继续促进 外部赠款的发展将促进我们对多因素老年疾病的了解。 在本供资周期内，PESC投资了625 000美元(总费用)，迄今已有31 出版物和向审查处调查人员提供的1350万美元的外部资金(总费用)。在第一年 下一个周期，三个新的PESS将得到初级和高级调查人员的支持：PES-1-分子 《社会差异的基础》(Pi，Morgan Levine，Ph.D.)；PES-2--剖析病毒的机制 老年人的易感性(岩崎明子博士)；以及PES-3感染和小胶质细胞屏障 干扰：妄想症后认知衰退的后果(PI，Jaime Grutzendler，医学博士)。

The primary goal of the Pilot/Exploratory Studies Core (PESC) is to facilitate the development of innovative and rigorous research that will enhance our understanding of the etiology, diagnosis, treatment, and prevention of multifactorial geriatric conditions (the focus of the Yale OAIC), leading ultimately to the development of efficacious and cost-effective interventions to increase or maintain the independence of older Americans. The Leader of the PESC, Dr. Albert Shaw, is nationally recognized for his research on aging of the human immune system. He holds a K24 award from the NIA focused on translational immunology, and he is PI of the Infectious Diseases T32 training grant at Yale. Since 2004, Dr. Shaw has also led the highly successful Biology of Aging seminar series and, as a result, he has an exceptional overview of aging research at Yale. Dr. Shaw will work closely with the Co-Leader of the PESC, Dr. Terri Fried, a leader in research on clinical decision-making in older adults with multiple conditions. The Specific Aims of the PESC are to: (1) solicit and select the most meritorious research proposals for pilot funding; (2) provide investigators of Pilot / Exploratory Studies (PESs) with access to resources from the Operations (RC1) and Biostatistics (RC2) Cores; (3) identify potential opportunities for collaboration among PESC investigators; (4) monitor the progress of PESs; (5) provide assistance so that the PESs can be successfully developed into independently funded grant applications; and (6) ensure the safety and protection of human subjects and vertebrate animals enrolled in PESs. In addition to traditional one-year PESs, we will continue an Expedited Pilot Program (EXPI), which will fund small grants capped at a maximum of $5000 that are awarded within 4 weeks of application. These grants are intended for research activities in which a rapid infusion of a relatively small amount of funds will facilitate a successful extramural grant application. PESs and EXPI awards will take full advantage of the resources and expertise available from the OAIC’s two Resource Cores. Priority for PESC funding will be given to junior investigators as well as to accomplished mid-career and senior investigators who wish to redirect or expand their research to the study of multifactorial geriatric conditions. By facilitating access to the OAIC research infrastructure, these mechanisms will continue to foster the development of external grants that will advance our understanding of multifactorial geriatric conditions. During the current funding cycle, the PESC invested $625,000 (total costs) that has resulted, to date, in 31 publications and $13.5 million in extramural funding (total costs) to OAIC investigators. During Year 1 of the next cycle, three new PESs will be supported from junior and senior investigators: PES-1—Molecular Underpinnings of Social Disparities (PI, Morgan Levine, Ph.D.); PES-2—Dissecting the Mechanisms of Viral Susceptibility in Older Adults (PI, Akiko Iwasaki, Ph.D.); and PES-3—Infections and Microglial Barrier Disruption: Consequences for Post-Delirium Cognitive Decline (PI, Jaime Grutzendler, M.D., Ph.D.).