Genetic Approaches to Development and Disease

项目总结 这项提案描述了一项新的博士培训计划，即发育和疾病的遗传方法 (GADD)在哥伦比亚大学欧文医学中心(CUIMC)，该中心培训年轻科学家使用 现代遗传学，以应对生物医学研究中的主要挑战。有必要对特定的 由于普遍使用易遗传的模式生物，对博士生进行了遗传方法方面的培训， 现代基因技术的进化，以及哺乳动物系统中基因组分析的复杂性， 包括人类病人。GADD计划就是为满足这一需求而设计的。 GADD项目的学生接受使用模型生物进行遗传分析的高级培训， 目前的遗传和基因组技术、生物统计学、遗传学史和现代遗传学伦理学。 GADD培训计划作为一个高度选择性的培训计划，汇集了动态的、良好的 哥伦比亚大学各系和研究中心资助的教职员工和优秀学生 基于他们的主题匹配、严谨的研究和指导能力。培训计划的特点是严格的 强调批判性思维以及写作和演示技能发展的课程，以及 定期反馈，并对每个学生进行个性化辅导。我们教员培训实验室的实习生 过去五年毕业的学生表现出出色的培训结果，并有合理的时间获得学位(略低于6 高比例的资助奖项(26%)和第一作者出版物(97%)，以及成功的研究， 教育或研究相关职业(94%)。GADD计划的一个主要目标是使 通过有效招聘、留住和支持的生物医学劳动力：URM学生占16% 在校学生。拟议的GADD培训补助金将提供学术、社会和职业发展 通过有组织的培训活动和密切监测学生进展情况，为所有学生提供支持 将取代以前的遗传与发育(G&D)培训补助金。总体而言，GADD计划 代表了一流的以遗传学为重点的研究生项目，该项目在培训方面取得了长期的成功 生物医学研究和现代培训领域的领先者计划在未来继续做出贡献。

PROJECT SUMMARY This proposal describes a new PhD training program, Genetic Approaches to Development and Disease (GADD) at Columbia University Irving Medical Center (CUIMC), which trains young scientists in the use of modern genetics to address major challenges in biomedical research. There is an essential need for specific training of PhD students in genetic approaches due to the prevalent use of genetically tractable model organisms, the evolution of modern genetic techniques, and the complexities of genomic analyses in mammalian systems, including human patients. The GADD program has been designed to meet this need. Students in the GADD program receive advanced training in genetic analyses using model organisms, current genetic and genomic techniques, biostatistics, history of genetics, and the ethics of modern genetics. The GADD training program functions as a highly selective training program that draws together dynamic, well- funded faculty and outstanding students from departments and research centers across Columbia University based on their thematic fit, rigorous research, and mentoring abilities. The training program features a rigorous curriculum that emphasizes critical thought and development of writing and presentation skills, together with regular feedback and individualized mentoring of each student. Trainees in our faculty training labs who have graduated in the last five years show excellent training outcomes, with reasonable time-to-degree (just under 6 years), a high percentage of funding awards (26%) and first-author publications (97%), and successful research, educational, or research-related careers (94%). A major goal of the GADD program is diversification of the biomedical workforce through effective recruitment, retention, and support: URM students represent 16% of current students. The proposed GADD training grant will provide academic, social, and career development support to all of its students through structured training activities and close monitoring of student progress and will replace the previous Genetics and Development (G&D) training grant. Overall, the GADD program represents a premier genetics-focused graduate program that has a long track-record of success in training leaders in biomedical research and a modern training plan to continue its contributions in the future.