Pathology and Bio-analytics Core

该中心的首要目标是了解糖尿病的病理生理学机制 肥胖和他们的心血管并发症。生物分析核心是 该中心将在科布雷第三阶段的演变中发挥关键作用。核心将呈现 为糖尿病样本的严格和全面的生物分析提供服务。会的 通过实验设计和最先进的技术专业知识提供智力投入 满足中心调查人员的需求。核心由一群杰出的科学家组成 在层析、质谱学、临床化学、心血管等领域具有专业知识 生理学和糖尿病。核心主任桑贾伊·斯里瓦斯塔瓦博士有超过25个 在分析生物化学和病理学、血管炎症、 动脉粥样硬化和糖尿病。他将监督核心的所有业务，并将与 中心调查人员和Cobre支持的试点项目负责人履行他们的分析 生物化学需要。核心技术总监Lorkiewicz博士在以下方面拥有丰富的经验 小分子化合物的稳定同位素标记和质谱分析。 他将协助中心的研究人员进行代谢组学、硫代色素和其他 色谱质谱联用分析。斯里瓦斯塔瓦博士和洛尔凯维奇博士将提供帮助 关于对初级调查人员进行生物分析分析的培训。在核心所获得的培训将 促进他们成长为科学家，并扩大他们的技术技能储备。核心是 配备最先进的临床化学和分析生化设备，并 位于迪利亚·巴克斯特大楼。除了满足眼镜蛇目前的要求外， 项目，核心将继续扩大其知识库和技术专长，以满足 该中心未来的需求。核心的长期目标是成为一个财政独立的 能够为研究人员提供尖端病理学和生物分析服务的实体 对糖尿病和心血管病理生理学感兴趣。在病理学方面继续保持卓越 分析将促进合作，这不仅将在财务上帮助核心，而且还将 推动糖尿病并发症防治领域的发展。

Overarching goal of the Center is to understand the mechanisms of pathophysiology of diabetes and obesity and their cardiovascular complications. The Bioanalytics Core is an integral part of the Center and will play a key role in the evolution of COBRE in Phase III. The Core will render services for rigorous and comprehensive bioanalytical analysis of diabetic specimens. It will provide intellectual input with experimental design and state-of-the-art technical expertise to address the needs of Center investigators. The Core consists of a group of outstanding scientists with expertise in chromatography, mass spectrometry, clinical chemistry, cardiovascular physiology and diabetes. Director of the Core, Dr. Sanjay Srivastava has more than twenty five years of research experience in analytical biochemistry and pathology, vascular inflammation, atherosclerosis and diabetes. He will oversee all the Core operations and will work closely with Center investigators and COBRE-supported pilot project leaders to fulfill their analytical biochemistry needs. Dr. Lorkiewicz, technical director of the Core has extensive experience in stable isotope labeling and mass spectrometric analyses of small molecular weight compounds. He will assist the Center investigators with their metabolomics, mercapturomics and other chromatography/mass spectrometry analyses. Drs. Srivastava and Lorkiewicz will provide hands on training to junior investigators for bioanalytical assays. The training acquired at the Core will facilitate them to grow as scientists and expand their repertoire of technical skills. The Core is equipped with state-of-the-art clinical chemistry and analytical biochemistry equipment and is located in the Delia Baxter Building. In addition to address the current requirements of the COBRE projects, the Core will continue to expand its knowledgebase and technical expertise to satisfy the future needs of the Center. Long term goal of the Core is to become a fiscally independent entity capable of providing cutting-edge pathology and bio-analytical services to researchers interested in diabetes and cardiovascular pathophysiology. Continued excellence in pathological analyses will foster collaborations which will not only help the Core financially, but will also advance the field in combatting diabetic complications.